Lethal Factor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Lethal Factor
  Conformer 1
(PDB)
1yqy (A)
  Conformer 2
(PDB)
1pwq (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 31 8.8   437 - 467
2 21 6.53   416 - 436
3 74 17.39   551 - 594   603 - 632
4 31 4.96   385 - 415
5 23 7.54   595 - 602   677 - 691

Sequence


           ________________________________________________________________________________________________________________________ 
 1yqy(A) : **************************************LSRYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSDFLSTEEKEFLKKLQIDIR 
         :                                                                                                                          
 1pwq(A) : ERNKTQEEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKAIGGKIYIVDGDITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYEPVLVIQSSEDYVENTEKALN 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________________________415__________________436____________________________46 
 1yqy(A) : DSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRG 
         :                                                                                                                          
 1pwq(A) : ------------------VYYEIGKILSRDILSKINQPYQKFLDVLNTIKNASDSDGQDLLFTNQLKEHPTDFSVEFLEQNSNEVQEVFAKAFAYYIEPQHRDVLQLYAPEAFNYMDKFN 
           __________________________________________________________________197__________________218____________________________24 

           7_______________________________________________________________________________________________________________________ 
 1yqy(A) : IFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNINQEWNKALGLPKYTKLITFN 
         :                                                                                                                          
 1pwq(A) : EQEINLSLEELKDQRMLSRYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRsNPLSEKEKEFLKKLKLDIQPY 
           9_______________________________________________________________________________________________________________________ 

           _____594_____602___________________________632__________________________________________________________________________ 
 1yqy(A) : VHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNGRFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHEFGHAVDDYAGYLLDKNQSD 
         :                                                                                                                          
 1pwq(A) : DINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLS 
           _____394_____402___________________________432__________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1yqy(A) : LVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEAFRLMHSTDHAERLKVQKNAPKTFQFINDQIKFIINSLV************************************************ 
         :                                                                                                                          
 1pwq(A) : PDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNINQEWNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGN 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1yqy(A) : ************************************************************************************************************************ 
         :                                                                                                                          
 1pwq(A) : GRFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHEFGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEAFRLMHS 
           ________________________________________________________________________________________________________________________ 

           ______________________________                                                                                           
 1yqy(A) : ******************************                                                                                           
         :                                                                                                                          
 1pwq(A) : TDHAERLKVQKNAPKTFQFINDQIKFIINS                                                                                           
           ______________________________                                                                                           

Morph

Morph animation in progress.
Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.


Show console


play backwards pause play forwards

Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 156.1 14.5 25.8   436 - 437 Bending Region Analysis
1 3 76.6 -60.2 73.5   467 - 551 Bending Region Analysis
4 2 145.8 3.1 80.2   415 - 416 Bending Region Analysis
3 5 176.6 -9.6 78.2   594 - 595   602 - 603   632 - 677 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 4

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 3 ———› Residue 5

Conformer 2 Contact:
Residue 5 ———› Residue 3

Movement classification: Hinge

PyMOL Script

Download and extract PyMOL PML script file Download