Bifunctional P-450/nadph-P450 Reductase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Bifunctional P-450/nadph-P450 Reductase
  Conformer 1
(PDB)
4kf2 (A)
  Conformer 2
(PDB)
1bvy (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 366 0.98   23 - 170   232 - 234   238 - 452
2 60 1.15   171 - 231   235 - 237

Sequence


           ________________________________________________________________________________________________________________________ 
 4kf2(A) : KEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFFGDGLVTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDI 
         :                                                                                                                          
 1bvy(B) : ******************NTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDI 
           ________________________________________________________________________________________________________________________ 

           _________________________________________166______________________________________________________________231___________ 
 4kf2(A) : AVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRA--dDPAYDENKRQFQEDIKVMNDLVDKIIADRKAS--qSDDLLTHMLNGKD 
         :                                                                                                                          
 1bvy(B) : AVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKD 
           _________________________________________166______________________________________________________________231___________ 

           ________________________________________________________________________________________________________________________ 
 4kf2(A) : PETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHR 
         :                                                                                                                          
 1bvy(B) : PETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHR 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________                         
 4kf2(A) : DKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGG*                         
         :                                                                                                                          
 1bvy(B) : DKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGI                         
           ________________________________________________________________________________________________                         

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
20.2
Translation
(A)
-1.6
Closure
(%)
92.6
Bending Residues
( green )
  166 - 171
  231 - 232
  234 - 252
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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