DynDom - Protein Domain Motions

Glutamate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Glutamate Dehydrogenase
Conformer 1 (PDB)	1hwy (A)
Conformer 2 (PDB)	1l1f (A)
Window Length	11
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	260	1.89	21 - 41 51 - 205 383 - 452 483 - 496
2	226	1.74	11 - 20 42 - 50 206 - 382 453 - 482

Sequence

`__________________20____26______________________50______________________________________________________________________` `1hwy(A) : ADREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRQTQEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSHQRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDV` `:` `1l1f(A) : *****DPNFFKMVEGFFDRGASIVEDKLVEDLRTRESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDV` `__________________24____30______________________54______________________________________________________________________` `__________________________________________________________________________________205___________________________________` `1hwy(A) : PFGGAKAGVKINPKNYTDEDLEKITRRFTMELAKKGFIGPGVDVPAPNMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFIENASYMSILGMTP` `:` `1l1f(A) : PFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTP` `__________________________________________________________________________________209___________________________________` `________________________________________________________________________________________________________________________` `1hwy(A) : GFGDKTFAVQGFGNVGLHSMRYLHRFGAKCVAVGESDGSIWNPDGIDPKELEDFKLQHGTILGFPKAKIYEGSILEVDCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPQADKIF` `:` `1l1f(A) : GFGDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIF` `________________________________________________________________________________________________________________________` `___________________382___________________________________________________________________452___________________________4` `1hwy(A) : LERNIMVIPDLYLNAGGVTVSYFQILKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTA` `:` `1l1f(A) : LERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTA` `___________________386___________________________________________________________________456___________________________4` `82___________________` `1hwy(A) : AYVNAIEKVFRVYNEAGVTFT` `:` `1l1f(A) : AYVNAIEKVFKVYNEAGVTFT` `86___________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	14.9
Translation (A)	-0.4
Closure (%)	73.6
Bending Residues ( green )	20 - 21 26 - 47 50 - 51 205 - 206 382 - 383 452 - 453 482 - 483
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

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