DynDom - Protein Domain Motions

Beta-Klotho

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Beta-Klotho
Conformer 1 (PDB)	5van (A)
Conformer 2 (PDB)	5vaq (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	441	0.6	56 - 76 81 - 507 851 - 858 863 - 863 892 - 894
2	413	0.47	77 - 80 508 - 850 859 - 862 864 - 891 895 - 966

Sequence

`___________76__80_______________________________________________________________________________________________________` `5van(A) : FSGDGRAIWSqLFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHL-gSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEP` `:` `5vaq(A) : FSGDGRAIWS-lFLYDTFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHLKgSSDSYIFLEKDLSALDFIGVSFYQFSISWPRLFPDGIVTVANAKGLQYYSTLLDALVLRNIEP` `___________76__80_______________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `5van(A) : IVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPQR` `:` `5vaq(A) : IVTLYHWDLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKYWITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLIKAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPQR` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `5van(A) : SENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTED` `:` `5vaq(A) : SENTMDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVLPIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQNVSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTED` `________________________________________________________________________________________________________________________` `___________________________________________________________________________507__________________________________________` `5van(A) : TTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPEqCTDFVNIKKQL` `:` `5vaq(A) : TTAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQDAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGFSLKESTPDVQGQFPCDFSWGVTESVLKPE-cTDFVNIKKQL` `___________________________________________________________________________507__________________________________________` `________________________________________________________________________________________________________________________` `5van(A) : EMLARMKVTHYRFALDWASVLPTGQLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGN` `:` `5vaq(A) : EMLARMKVTHYRFALDWASVLPTGQLSAVNRQALRYYRCVVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNPSTAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNRSGN` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `5van(A) : DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHF` `:` `5vaq(A) : DTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSLHADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGDYPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDFCALNHF` `________________________________________________________________________________________________________________________` `_____________________850_____858_862__________________________891_______________________________________________________` `5van(A) : TTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFT` `:` `5vaq(A) : TTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSPTRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALEDDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEKSKPRFGFFT` `_____________________850_____858_862__________________________891_______________________________________________________` `_______________________` `5van(A) : SDFKAKSSIQFYNKVISSRGFP*` `:` `5vaq(A) : SDFKAKSSIQFYNKVISSRGFPF` `_______________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.

play backwards

pause

play forwards

Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	5.9
Translation (A)	-0.5
Closure (%)	76.7
Bending Residues ( green )	76 - 78 80 - 81 507 - 508 850 - 856 858 - 859 862 - 864 891 - 892 894 - 895
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

Download and extract PyMOL PML script file

Download