Cyclin-Dependent Kinase 5

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Cyclin-Dependent Kinase 5
  Conformer 1
(PDB) 		4au8 (A)
  Conformer 2
(PDB) 		3o0g (A)
  Window Length 9
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 216 1.67   54 - 63   78 - 285
2 51 0.86   5 - 53   64 - 77

Sequence


           _______________________________________________48_____________63____________77__________________________________________ 
 4au8(A) : GSQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV---------pSSALREICLLKELKHKNIVRLHDVLH---kLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 
         :                                                                                                                          
 3o0g(A) : *MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHS 
           _______________________________________________48_____________63____________77__________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4au8(A) : RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVR--sAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 
         :                                                                                                                          
 3o0g(A) : RNVLHRDLKPQNLLINRNGELKLANFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________                                                                       
 4au8(A) : PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF                                                                       
         :                                                                                                                          
 3o0g(A) : PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF                                                                       
           __________________________________________________                                                                       

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		12.0
Translation
(A) 		0.6
Closure
(%) 		62.3
Bending Residues
( green ) 		  48 - 54
  63 - 64
  77 - 78
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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