DynDom - Protein Domain Motions

Extracellular Calcium-Sensing Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Extracellular Calcium-Sensing Receptor
Conformer 1 (PDB)	5fbk (A)
Conformer 2 (PDB)	5k5t (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	292	1.17	24 - 191 323 - 483
2	184	0.86	192 - 322 484 - 537

Sequence

`________________________________________________________________________________________________________________________` `5fbk(A) : PDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIA` `:` `5k5t(A) : GPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCN-----pSTIA` `________________________________________________________________________________________________________________________` `________________________________________________191_____________________________________________________________________` `5fbk(A) : VVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDI-iDFSELISQYSDEEEIQHVVEVIQ` `:` `5k5t(A) : VVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQ` `________________________________________________191_____________________________________________________________________` `__________________________________________________________321___________________________________________________________` `5fbk(A) : NSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHL--------------------` `:` `5k5t(A) : NSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEES` `__________________________________________________________321___________________________________________________________` `___________________________________________________________________________________________________483__________________` `5fbk(A) :` `-----------rPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDE-gDLVGNYSIINWHLSPED` `:` `5k5t(A) :` `GDRFSQSSTAFRPLCTGDENINSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPED` `___________________________________________________________________________________________________483__________________` `_______________________________________________________________________________________________________` `5fbk(A) : GSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPF***************************************************************` `:` `5k5t(A) : GSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEI` `_______________________________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	30.6
Translation (A)	-1.8
Closure (%)	100.0
Bending Residues ( green )	191 - 194 321 - 323 483 - 489
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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