DynDom - Protein Domain Motions

Insulin-Like Growth Factor 1 Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Insulin-Like Growth Factor 1 Receptor
Conformer 1 (PDB)	6jk8 (A)
Conformer 2 (PDB)	6jk8 (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	155	1.47	328 - 482
2	277	2.0	33 - 325
3	336	7.22	483 - 672 730 - 926

Sequence

`________________________________________________________________________________________________________________________` `6jk8(A) : EICGPGIDIRNDYQQLKRLENCTVIEGYLHILLIS--rSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLS` `:` `6jk8(B) : EICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKArSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLS` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6jk8(A) : TVDWSLILDAVSNNYIVGNKPPKECGDLCP-cEKTTINNEYNYRCWTTNRCQKMCPSTC---aCTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRD` `:` `6jk8(B) : TVDWSLILDAVSNNYIVGNKPPKECGDLCPGcEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRD` `________________________________________________________________________________________________________________________` `_______________________________________322______________________________________________________________________________` `6jk8(A) : FCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLS` `:` `6jk8(B) : FCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLS` `_______________________________________322______________________________________________________________________________` `____________________________________________________________________________479_________________________________________` `6jk8(A) : FLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDL` `:` `6jk8(B) : FLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDL` `____________________________________________________________________________479_________________________________________` `________________________________________________________________________________________________________________________` `6jk8(A) : ISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGN` `:` `6jk8(B) : ISFTVYYKEAPFKNVTEY--------nSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGN` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6jk8(A) : LSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYAgPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPyPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFV` `:` `6jk8(B) : LSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRK-------------eKQAEKEEAEYRKVFENFLHNSI----eYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFV` `________________________________________________________________________________________________________________________` `_____________________________________________________________________________________________________________` `6jk8(A) : FARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGY` `:` `6jk8(B) : FARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAK***` `_____________________________________________________________________________________________________________`

Morph

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	55.8
Translation (A)	3.5
Closure (%)	39.6
Bending Residues ( green )	322 - 330
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	99.6
Translation (A)	-1.0
Closure (%)	91.8
Bending Residues ( green )	479 - 489
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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