L-Lactate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name L-Lactate Dehydrogenase
  Conformer 1
(PDB) 		2v6m (A)
  Conformer 2
(PDB) 		2v7p (A)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 227 1.87   25 - 139   142 - 164   234 - 326
2 75 0.82   140 - 141   165 - 233

Sequence


           _________________________________________________________________________________________________________________139____ 
 2v6m(A) : MKVGIVGSGMVGSATAYALALLGVAREVVLVDLDRKLAQAHAEDILHATPFAHPVWVRAGSYGDLEGARAVVLAAGVAQRPGETRLQLLDRNAQVFAQVVPRVLEAAPEAVLLVATNPVD 
         :                                                                                                                          
 2v7p(A) : MKVGIVGSGMVGSATAYALALLGVAREVVLVDLDRKLAQAHAEDILHATPFAHPVWVRAGSYGDLEGARAVVLAAGVAQRPGETRLQLLDRNAQVFAQVVPRVLEAAPEAVLLVATNPVD 
           _________________________________________________________________________________________________________________139____ 

           __________________164______________________________________________________________________233__________________________ 
 2v6m(A) : VMTQVAYRLSGLPPGRVVGSGTILDTARFRALLAEYLRVAPQSVHAYVLGEHGDSEVLVWSSAQVGGVPLLEFAEARGRALSPEDRARIDEGVRRAAYRIIEGKGATYYGIGAGLARLVR 
         :                                                                                                                          
 2v7p(A) : VMTQVAYRLSGLPPGRVVGSGTILDTARFRALLAEYLRVAPQSVHAYVLGEHGDSEVLVWSSAQVGGVPLLEFAEARGRALSPEDRARIDEGVRRAAYRIIEGKGATYYGIGAGLARLVR 
           __________________164______________________________________________________________________233__________________________ 

           ______________________________________________________________________                                                   
 2v6m(A) : AILTDEKGVYTVSAFTPEVEGVLEVSLSLPRILGAGGVEGTVYPSLSPEEREALRRSAEILKEAAFALGF                                                   
         :                                                                                                                          
 2v7p(A) : AILTDEKGVYTVSAFTPEVEGVLEVSLSLPRILGAGGVEGTVYPSLSPEEREALRRSAEILKEAAFALGF                                                   
           ______________________________________________________________________                                                   

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		13.5
Translation
(A) 		-0.2
Closure
(%) 		52.2
Bending Residues
( green ) 		  139 - 142
  164 - 165
  233 - 234
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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