Map Kinase-Activated Protein Kinase 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Map Kinase-Activated Protein Kinase 2
  Conformer 1
(PDB) 		1nxk (A)
  Conformer 2
(PDB) 		1ny3 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 227 1.2   48 - 59   89 - 89   91 - 119   124 - 343
2 34 0.99   60 - 88   90 - 90   120 - 123

Sequence


           ________________59___________________________88____________________________119_123______________________________________ 
 1nxk(A) : QFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK-lQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIV-eCLDGGELFSRIQDRaFTEREAS 
         :                                                                                                                          
 1ny3(A) : ****FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD---tEREAS 
           ________________59___________________________88____________________________119_123______________________________________ 

           ________________________________________________________________________________________________________________________ 
 1nxk(A) : EI-kSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT--pYYVAPEVLGPEKYDKSCD-wSLGVI-yILLCGYPPFYSNHGLAISPGkTRIR-gQYEFPNPEWSEV 
         :                                                                                                                          
 1ny3(A) : EIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHpYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYS--gM-----KTRIRMGQYEFPNPEWSEV 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________________                                                                      
 1nxk(A) : SEEVK-lIRNLLKTEPTQR-tITEF-nHPWI-qSTKVPQTPLHTSRVLKED                                                                      
         :                                                                                                                          
 1ny3(A) : SEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED                                                                      
           ___________________________________________________                                                                      

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		12.9
Translation
(A) 		0.3
Closure
(%) 		39.6
Bending Residues
( green ) 		  59 - 60
  88 - 91
  119 - 120
  123 - 124
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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