Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Metabotropic Glutamate Receptor Subtype 1
  Conformer 1
(PDB) 		1ewk (B)
  Conformer 2
(PDB) 		5c5c (A)
  Window Length 11
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 262 1.64   41 - 210   341 - 475
2 147 3.5   211 - 340   476 - 505

Sequence


           ________________________________________________________________________________________________________________________ 
 1ewk(B) : QRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIR---kP--IAGVIGPGSSSVAIQVQNLLQLF 
         :                                                                                                                          
 5c5c(A) : *PHSIRIEGDVTLGGLFPVHAKGPS-GVP---CGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIkPEKVVGVIGASGSSVSIMVANILRLF 
           ________________________________________________________________________________________________________________________ 

           _____________________________210________________________________________________________________________________________ 
 1ewk(B) : DIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEG-LCIAHSDKIYSNAGEKS--FDRLLRKLRERLPKARVVVCFCEGMT 
         :                                                                                                                          
 5c5c(A) : QIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLSIAQSVRIPQERKDRTIDFDRIIKQLLDT-PNSRAVVIFANDED 
           _____________________________204________________________________________________________________________________________ 

           __________________________________________340___________________________________________________________________________ 
 1ewk(B) : VRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESL--EENYVQDSKMGFV 
         :                                                                                                                          
 5c5c(A) : IKQILAAAKRADQVGHFLWVGSDSW---------hEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLd----------RKCTGQERIGKDSNYEQEGKVQFV 
           __________________________________________336___________________________________________________________________________ 

           ___________________________________________________________475______________________________________                     
 1ewk(B) : INAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGV-LNIDDYKI                     
         :                                                                                                                          
 5c5c(A) : IDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNpG---YRLIGQWTDELQLNIEDMQW                     
           ___________________________________________________________473______________________________________                     

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		21.8
Translation
(A) 		1.4
Closure
(%) 		72.9
Bending Residues
( green ) 		  210 - 211
  340 - 344
  475 - 476
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

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