DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor Subtype 1
Conformer 1 (PDB)	2e4u (A)
Conformer 2 (PDB)	2e4u (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	451	0.15	32 - 508
2	57	0.26	509 - 565

Sequence

`________________________________________________________________________________________________________________________` `2e4u(A) : **RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLiPLLIAGVIGGSYSSVSIQVANLLRLFQIP` `:` `2e4u(B) : FMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLiPLLIAGVIGGSYSSVSIQVANLLRLFQIP` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2e4u(A) : QISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAA` `:` `2e4u(B) : QISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAA` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2e4u(A) : ANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQqVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCP` `:` `2e4u(B) : ANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQqVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCP` `________________________________________________________________________________________________________________________` `___________________________________________________________________________________________507__________________________` `2e4u(A) : QTTKLCDAMKILDGKKLYKEYLLKIQFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIP` `:` `2e4u(B) : QTTKLCDAMKILDGKKLYKEYLLKIQFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIP` `___________________________________________________________________________________________507__________________________` `__________________________________` `2e4u(A) : CEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPE` `:` `2e4u(B) : CEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPE` `__________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	16.5
Translation (A)	0.0
Closure (%)	1.5
Bending Residues ( green )	507 - 510
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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