Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Metabotropic Glutamate Receptor Subtype 1
  Conformer 1
(PDB) 		4xar (A)
  Conformer 2
(PDB) 		3sm9 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 265 1.65   32 - 194   327 - 464
2 164 1.5   195 - 326   465 - 498

Sequence


           ________________________________________________________________________________________________________________________ 
 4xar(A) : RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLlLIAGVIGGSYSSVSIQVANLLRLFQIPQISY 
         :                                                                                                                          
 3sm9(A) : RREIKIEGDLVLGGLFPINEKGT-tEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASlL-IAGVIGGSYSSVSIQVANLLRLFQIPQISY 
           ________________________________________________________________________________________________________________________ 

           ____________________194_________________________________________________________________________________________________ 
 4xar(A) : ASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNISIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRA 
         :                                                                                                                          
 3sm9(A) : ASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNISIATAEKVGR--iRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRA 
           ____________________169_________________________________________________________________________________________________ 

           ________________________________326_____________________________________________________________________________________ 
 4xar(A) : NASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSL----rVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPN 
         :                                                                                                                          
 3sm9(A) : NASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQnHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPN 
           ________________________________301_____________________________________________________________________________________ 

           __________________________________________464____________________________________________                                
 4xar(A) : TTKLCDAMKILDGKKLYKDYLLKINFTAPdADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSE                                
         :                                                                                                                          
 3sm9(A) : TTKLCDAMKILDGKKLYKDYLLKINFTAPFNdSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWS********                                
           __________________________________________439____________________________________________                                

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		26.7
Translation
(A) 		0.0
Closure
(%) 		96.4
Bending Residues
( green ) 		  194 - 195
  326 - 327
  464 - 465
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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