DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor Subtype 1
Conformer 1 (PDB)	4xar (A)
Conformer 2 (PDB)	6b7h (A)
Window Length	7
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	382	0.5	35 - 215 220 - 241 266 - 276 296 - 502
2	20	0.5	216 - 219 244 - 254 277 - 281

Sequence

`________________________________________________________________________________________________________________________` `4xar(A) : RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASL-lLIAGVIGGSYSSVSIQVANLLRLFQIPQIS` `:` `6b7h(A) : RREIKI-gDLVLGGLFPINEK----eECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLpLLIAGVIGGSYSSVSIQVANLLRLFQIPQIS` `________________________________________________________________________________________________________________________` `__________________________________________215_219___________________241__________254___________________276__281_________` `4xar(A) : YASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNISIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASR` `:` `6b7h(A) : YASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNISIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASR` `__________________________________________215_219___________________241__________254___________________276__281_________` `________________________________________________________________________________________________________________________` `4xar(A) : ANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLrVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTK` `:` `6b7h(A) : ANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLrVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTK` `________________________________________________________________________________________________________________________` `______________________________________________________________________________________` `4xar(A) : LCDAMKILDGKKLYKDYLLKINFTAPdADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSE` `:` `6b7h(A) : LCDAMKILDGKKLYKDYLLKINFTAPdADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSE` `______________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	4.7
Translation (A)	0.0
Closure (%)	56.9
Bending Residues ( green )	215 - 216 219 - 220 241 - 244 254 - 266 276 - 277 281 - 296
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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