DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor 2
Conformer 1 (PDB)	4xaq (A)
Conformer 2 (PDB)	5kzq (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	266	0.6	26 - 186 321 - 450
2	168	0.61	187 - 320 451 - 485

Sequence

`________________________________________________________________________________________________________________________` `4xaq(A) : AKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASL-tAITGVIGGSYSDVSIQVANLLRLFQIPQI` `:` `5kzq(A) : KVLTLEGDLVLGGLFPVHQK--pAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLpTAITGVIGGSYSDVSIQVANLLRLFQIPQI` `________________________________________________________________________________________________________________________` `____________________186_________________________________________________________________________________________________` `4xaq(A) : SYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNISVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQ` `:` `5kzq(A) : SYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQ` `____________________186_________________________________________________________________________________________________` `__________________________________320___________________________________________________________________________________` `4xaq(A) : RLNASFTWVASDGWGALEEVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNT` `:` `5kzq(A) : RLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNT` `__________________________________320___________________________________________________________________________________` `__________________________________________448___________________________________________________________________________` `4xaq(A) : TRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPW********************************` `:` `5kzq(A) : TRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAG-gRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCI` `__________________________________________448___________________________________________________________________________` `____________________________` `4xaq(A) : **************************` `:` `5kzq(A) : PCQPYEYRLDEFTCADCGLGYWPNASLT` `____________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.

play backwards

pause

play forwards

Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	27.8
Translation (A)	0.6
Closure (%)	95.4
Bending Residues ( green )	186 - 192 320 - 322 448 - 452
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

Download and extract PyMOL PML script file

Download