Metabotropic Glutamate Receptor 8

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Metabotropic Glutamate Receptor 8
  Conformer 1
(PDB) 		6bsz (A)
  Conformer 2
(PDB) 		6e5v (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 259 0.67   40 - 198   335 - 469
2 168 0.48   199 - 334   470 - 503

Sequence


           ________________________________________________________________________________________________________________________ 
 6bsz(A) : AHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQA----kISGVIGAAASSVSIMVANILRLFKIPQIS 
         :                                                                                                                          
 6e5v(A) : *HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIpDKISGVIGAAASSVSIMVANILRLFKIPQIS 
           ________________________________________________________________________________________________________________________ 

           ____________________198_________________________________________________________________________________________________ 
 6bsz(A) : YASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVSIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAK 
         :                                                                                                                          
 6e5v(A) : YASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVSIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAK 
           ____________________198_________________________________________________________________________________________________ 

           ____________________________________334_________________________________________________________________________________ 
 6bsz(A) : KLQQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLkCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG 
         :                                                                                                                          
 6e5v(A) : KLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKL-cTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPG 
           ____________________________________334_________________________________________________________________________________ 

           ____________________________________465__________________________________________________                                
 6bsz(A) : YIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASE                                
         :                                                                                                                          
 6e5v(A) : YIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQIT--sTEYKVIGHWTNQLHLKVEDMQWA**********                                
           ____________________________________465__________________________________________________                                

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		14.1
Translation
(A) 		0.3
Closure
(%) 		99.2
Bending Residues
( green ) 		  198 - 199
  334 - 335
  465 - 473
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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