Mitogen-Activated Protein Kinase 8

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Mitogen-Activated Protein Kinase 8
  Conformer 1
(PDB) 		3elj (A)
  Conformer 2
(PDB) 		1ukh (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 208 0.94   81 - 86   111 - 169   171 - 335
2 109 2.31   11 - 80   87 - 110   170 - 170   336 - 361

Sequence


           ________________________________________________________________________80____86_____________________110________________ 
 3elj(A) : DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHE 
         :                                                                                                                          
 1ukh(A) : **NFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHE 
           ________________________________________________________________________80____86_____________________110________________ 

           ________________________________________169_____________________________________________________________________________ 
 3elj(A) : RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLsFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 
         :                                                                                                                          
 1ukh(A) : RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-----------yYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKL 
           ________________________________________169_____________________________________________________________________________ 

           _______________________________________________________________________________334_________________________              
 3elj(A) : QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPeREHTIEEWKELIYKEVMDLE              
         :                                                                                                                          
 1ukh(A) : QPTVRTYVENRPKYAGYSFEKLFPDVLFP-----nKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKi-------EEWKELIYKEVMDL*              
           _______________________________________________________________________________334_________________________              

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		14.3
Translation
(A) 		-1.9
Closure
(%) 		79.5
Bending Residues
( green ) 		  80 - 81
  86 - 87
  110 - 111
  169 - 171
  334 - 337
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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