DynDom - Protein Domain Motions

Myosin Heavy Chain Isoform A

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Myosin Heavy Chain Isoform A
Conformer 1 (PDB)	3i5h (A)
Conformer 2 (PDB)	3i5f (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	434	2.25	3 - 227 252 - 266 451 - 461 491 - 516 664 - 834
2	367	3.35	228 - 251 267 - 450 462 - 490 517 - 663

Sequence

`________________________________________________________________________________________________________________________` `3i5h(A) : MTMDFSDPDMEFLCLTRQKLMEATSIPFDGKKNCWVPDPDFGFVGAEIQSTKGDEVTVKTDKTQETRVVKKDDIGQRNPPKFEMNMDMANLTFLNEASILHNLRSRYESGFIYTYSGLFC` `:` `3i5f(A) : MTMDFSDPDMEFLCLTRQKLMEATSIPFDGKKNCWVPDPDFGFVGAEIQSTKGDEVTVKTDKTQETRVVKKDDIGQRNPPKFEMNMDMANLTFLNEASILHNLRSRYESGFIYTYSGLFC` `________________________________________________________________________________________________________________________` `_________________________________________________________________________196_______________________________________251__` `3i5h(A) : IAINPYRRLPIYTQGLVDKYRGKRRAEMPPHLFSIADNAYQYMLQDRENQSMLITGESGAGKTENTKKVIQYFALVAASLA-GkGTLEDQIVQCNPVLEAYGNAKTTRNNNSSRFGKFIR` `:` `3i5f(A) : IAINPYRRLPIYTQGLVDKYRGKRRAEMPPHLFSIADNAYQYMLQDRENQSMLITGESGAGKTENTKKVIQYFALVAASLAeKKGTLEDQIVQCNPVLEAYGNAKTTRNNNSSRFGKFIR` `_________________________________________________________________________196_______________________________________251__` `__________266___________________________________________________________________________________________________________` `3i5h(A) : IHFGTQGKIAGADIETYLLEKSRVTYQQSAERNYHIFYQLLSPAFPENIEKILAVPDPGLYGFINQGTLTVDGIDDEEEMGLTDTAFDVLGFTDEEKLSMYKCTGCILHLGEMKWKQRGE` `:` `3i5f(A) : IHFGTQGKIAGADIETYLLEKSRVTYQQSAERNYHIFYQLLSPAFPENIEKILAVPDPGLYGFINQGTLTVDGIDDEEEMGLTDTAFDVLGFTDEEKLSMYKCTGCILHLGEMKWKQRGE` `__________266___________________________________________________________________________________________________________` `__________________________________________________________________________450________461__________________________490___` `3i5h(A) : QAEADGTAEAEKVAFLLGVNAGDLLKCLLKPKIKVGTEYVTQGRNKDQVTNSIAALAKSLYDRMFNWLVRRVNQTLDTKAKRQFFIGVLDIAGFEIFDFNSFEQLCINYTNERLQQFFNH` `:` `3i5f(A) : QAEADGTAEAEKVAFLLGVNAGDLLKCLLKPKIKVGTEYVTQGRNKDQVTNSIAALAKSLYDRMFNWLVRRVNQTLDTKAKRQFFIGVLDIAGFEIFDFNSFEQLCINYTNERLQQFFNH` `__________________________________________________________________________450________461__________________________490___` `___________________515__________________________________________________________________________________________________` `3i5h(A) : HMFVLEQEEYKKEGIVWEFIDFGLDLQACIELIEKPMGILSILEEECMFPKASDTSFKNKLYDNHLGKNPMFGKPKPPKAGCAEAHFCLHHYAGSVSYSIAGWLDKNKDPINENVVELLQ` `:` `3i5f(A) : HMFVLEQEEYKKEGIVWEFIDFGLDLQACIELIEKPMGILSILEEECMFPKASDTSFKNKLYDNHLGKNPMFGKPKPPKAGCAEAHFCLHHYAGSVSYSIAGWLDKNKDPINENVVELLQ` `___________________515__________________________________________________________________________________________________` `_______________________________663______________________________________________________________________________________` `3i5h(A) : NSKEPIVKMLFT-aFQTISSVHKESLNKLMKNLYSTHPHFVRCIIPNELKTPGLIDAALVLHQLRCNGVLEGIRICRKGFPNRIIYSEFKQRYSILAPNAVPSGFADGKVVTDKALSALQ` `:` `3i5f(A) : NSKEPIVKMLFTPaFQTISSVHKESLNKLMKNLYSTHPHFVRCIIPNELKTPGLIDAALVLHQLRCNGVLEGIRICRKGFPNRIIYSEFKQRYSILAPNAVPSGFADGKVVTDKALSALQ` `_______________________________663______________________________________________________________________________________` `__________________________________________________________________________________________` `3i5h(A) : LDPNEYRLGNTKVFFKAGVLGMLEDMRDERLSKIISMFQAHIRGYLMRKAYKKLQDQRIGLTLIQRNVRKWLVLRNWEWWRLFNKVKPLL` `:` `3i5f(A) : LDPNEYRLGNTKVFFKAGVLGMLEDMRDERLSKIISMFQAHIRGYLMRKAYKKLQDQRIGLTLIQRNVRKWLVLRNWEWWRLFNKVKPLL` `__________________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	17.8
Translation (A)	3.2
Closure (%)	95.3
Bending Residues ( green )	196 - 228 251 - 252 266 - 267 450 - 451 461 - 462 490 - 491 515 - 517 663 - 664
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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