Nad-Dependent Deacetylase Sirtuin-3, Mitochondrial

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Nad-Dependent Deacetylase Sirtuin-3, Mitochondrial
  Conformer 1
(PDB) 		3gls (A)
  Conformer 2
(PDB) 		3glt (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 170 0.54   124 - 152   202 - 247   298 - 392
2 99 2.3   153 - 201   248 - 297

Sequence


           _____________________________152______________________________________________201_______________________________________ 
 3gls(A) : *KLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP 
         :                                                                                                                          
 3glt(A) : GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP 
           _____________________________152______________________________________________201_______________________________________ 

           ____247_______________________________________________297_______________________________________________________________ 
 3gls(A) : ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV 
         :                                                                                                                          
 3glt(A) : ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV 
           ____247_______________________________________________297_______________________________________________________________ 

           __________________________________                                                                                       
 3gls(A) : AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKL                                                                                       
         :                                                                                                                          
 3glt(A) : AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKL                                                                                       
           __________________________________                                                                                       

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		18.0
Translation
(A) 		-0.8
Closure
(%) 		99.0
Bending Residues
( green ) 		  152 - 153
  201 - 203
  247 - 248
  297 - 300
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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