DynDom - Protein Domain Motions

Nonstructural Protein V

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Nonstructural Protein V
Conformer 1 (PDB)	2hye (B)
Conformer 2 (PDB)	5hxb (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	27	8.2	124 - 150
2	23	10.71	32 - 54
3	41	11.94	172 - 212

Sequence

`________________________________________________________________________________________________________________________` `2hye(B) : **********************************************************************************************************************` `:` `5hxb(B) : SYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAlRPVKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNACILEYKQsIDIITRAHGNVQDRIGRPSETGIIGIIDP` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2hye(B) : ********************************************************************************************************************` `:` `5hxb(B) : ECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2hye(B) : ********************************************************************************************************************` `:` `5hxb(B) : AIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKtLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNqGSYVVAMETFTNLGPIVDMCVVDqGQGQLVTCSGAF` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2hye(B) : ********************************************************************************************************************` `:` `5hxb(B) : KEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPeTDDTLVLSFVGQTRVLMLNGEEVEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISVASCN` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2hye(B) : *****************************************************************************PDEINKLIETGLNTVEYFTSQQVTGTSSLGKNTIPPGVT` `:` `5hxb(B) : SSQVVVAVGRALYYLQIHPQELRQISHTEMEHEVACLDITPLsNGLSPLCAIGLWTDISARILKLPSFELhKEMLGGiIPRSILMTTFESSHYLLCALGDGALFYFGLNIETGLLSDRKK` `________________________________________________________________________________________________________________________` `____54___________________________________________________________________150____________________________________________` `2hye(B) : GLLTNApKIAIVPADDKTVPGKPIPNPLLGLDSTPSTQTVLDLSGKTLPSGSYKGVKLAKFGKENLMTRFIEEPRENPdFKRGRDTGGFHRREYSIGWVGDEVKVTEWCNPSCSPITAAA` `:` `5hxb(B) : VTLGTQPTVLRTFRSsTTNVFACSDRPTVIYSnHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDtTALRP` `___634___________________________________________________________________706____________________________________________` `________________________________________________________________________________________________________________________` `2hye(B) : RRFECTCHQCPVTCSECERDT***********************************************************************************************` `:` `5hxb(B) : SASTQALSSSVSSSKLeEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINST` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2hye(B) : ********************************************************************************************************************` `:` `5hxb(B) : VRLYEWTTEKELRTECNHYNNIMA----LYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDeERQHLQEVGLFHLGEFVNVFCH` `________________________________________________________________________________________________________________________` `_______________________________________________________________________________________________________________________` `2hye(B) : *********************************************************************************************************************` `:` `5hxb(B) : GSLVMQNtQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTkTEPATGFIDGDLIESFLDISRPKMQEVVANLQYDDGkREATADDLIKVVEELTRIH` `_______________________________________________________________________________________________________________________`

Morph

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Status: Initialising

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	148.5
Translation (A)	17.0
Closure (%)	80.5
Bending Residues ( green )	54 - 124
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	107.3
Translation (A)	-15.2
Closure (%)	97.3
Bending Residues ( green )	150 - 172
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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