Proto-Oncogene Tyrosine-Protein Kinase Abl1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Proto-Oncogene Tyrosine-Protein Kinase Abl1
  Conformer 1
(PDB) 		2hyy (A)
  Conformer 2
(PDB) 		2fo0 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 73 14.82   360 - 367   398 - 420   424 - 445   474 - 493
2 44 9.67   347 - 359   421 - 423   446 - 473

Sequence


           ________________________________________________________________________________________________________________________ 
 2hyy(A) : ****************************************************************************************WEMERTDITMKHKLGGGQYGEVYEGVWKKYSL 
         :                                                                                                                          
 2fo0(A) : ARWNkENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLR 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________________________________________________359___________________________ 
 2hyy(A) : TVAVKTLK-dTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR 
         :                                                                                                                          
 2fo0(A) : YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKE 
           __________________________________________________________________________________________278___________________________ 

           _______________________________420______________________445_________________________473_________________________________ 
 2hyy(A) : LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ******** 
         :                                                                                                                          
 2fo0(A) : AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 
           _______________________________339______________________364_________________________392_________________________________ 

           _________________________________________________________________________________________________________                
 2hyy(A) : *********************************************************************************************************                
         :                                                                                                                          
 2fo0(A) : APESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELG                
           _________________________________________________________________________________________________________                

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.


Show console


play backwards pause play forwards

Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		162.5
Translation
(A) 		-1.3
Closure
(%) 		10.0
Bending Residues
( green ) 		  359 - 360
  420 - 421
  423 - 425
  445 - 446
  473 - 474
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

Download and extract PyMOL PML script file Download