Proto-Oncogene Tyrosine-Protein Kinase Fes/fps

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Proto-Oncogene Tyrosine-Protein Kinase Fes/fps
  Conformer 1
(PDB) 		3bkb (A)
  Conformer 2
(PDB) 		3cbl (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 271 0.76   464 - 468   553 - 818
2 68 0.58   460 - 463   469 - 552

Sequence


           _______________463__468_________________________________________________________________________________552_____________ 
 3bkb(A) : ***PEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWVLNHEDLVLGE 
         :                                                                                                                          
 3cbl(A) : SMIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQ--qEYVLSV-----pRHFII----nLYRL----fPSIPLLIDHLLSTQQPL-----vVLHRAVPKDKWVLNHEDLVLGE 
           _______________463__468_________________________________________________________________________________552_____________ 

           ________________________________________________________________________________________________________________________ 
 3bkb(A) : QIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLA 
         :                                                                                                                          
 3cbl(A) : QIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLA 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3bkb(A) : ARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRP 
         :                                                                                                                          
 3cbl(A) : ARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRP 
           ________________________________________________________________________________________________________________________ 

           ________________                                                                                                         
 3bkb(A) : SFSTIYQELQSIRKRH                                                                                                         
         :                                                                                                                          
 3cbl(A) : SFSTIYQELQSIRKRH                                                                                                         
           ________________                                                                                                         

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		6.7
Translation
(A) 		0.2
Closure
(%) 		90.3
Bending Residues
( green ) 		  463 - 464
  468 - 470
  552 - 553
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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