DynDom - Protein Domain Motions

Pyruvate Kinase Isozymes M1/m2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Pyruvate Kinase Isozymes M1/m2
Conformer 1 (PDB)	4fxj (D)
Conformer 2 (PDB)	4fxf (D)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	396	1.05	32 - 117 220 - 529
2	102	0.82	118 - 219

Sequence

`___________________________________________________________________________________________117__________________________` `4fxj(D) : DTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKIT` `:` `4fxf(D) : ******MCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKIT` `___________________________________________________________________________________________117__________________________` `_______________________________________________________________________217______________________________________________` `4fxj(D) : LDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGK` `:` `4fxf(D) : LDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGK` `_______________________________________________________________________217______________________________________________` `________________________________________________________________________________________________________________________` `4fxj(D) : NIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQNLIAR` `:` `4fxf(D) : NIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQNLIAR` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `4fxj(D) : EAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFF` `:` `4fxf(D) : EAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFF` `________________________________________________________________________________________________________________________` `____________________________` `4fxj(D) : KKGDVVIVLTGWRPGSGFTNTMRVVPVP` `:` `4fxf(D) : KKGDVVIVLTGWRPGSGFTNTMRVVPVP` `____________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	42.4
Translation (A)	0.0
Closure (%)	99.1
Bending Residues ( green )	117 - 118 217 - 224
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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