Pyruvate Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Pyruvate Kinase
  Conformer 1
(PDB) 		1a49 (A)
  Conformer 2
(PDB) 		1pkl (G)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 394 2.2   26 - 116   219 - 528
2 99 2.02   117 - 218

Sequence


           ______________________________________________________________________________________________________116_______________ 
 1a49(A) : IQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVETLKEMIKSGMNVARMNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEV 
         :                                                                                                                          
 1pkl(G) : ************SQLAHNLTLSIFDPVANYRAARIICTIGPSTQSVEALKGLIQSGMSVARMNFSHGSHEYHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGQFVG-GDAVM 
           _______________________________________________________________________________________________________87_______________ 

           _____________________________________________________________________________________218________________________________ 
 1a49(A) : ELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVDVGSKVYVDDGLISLQVK-QKGPDFLVTEVENGGFLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADV 
         :                                                                                                                          
 1pkl(G) : E--RGATCYVTTDPAFADKGTKDKFYIDYQNLSKVVRPGNYIYIDDGILILQVQSHEDEQTLECTVTNSHTISDRRGVNLPGCDVDLPAVSAKDRVDLQFGVEQGVDMIFASFIRSAEQV 
           _____________________________________________________________________________________187________________________________ 

           ________________________________________________________________________________________________________________________ 
 1a49(A) : HEVRKILGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMIIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYP 
         :                                                                                                                          
 1pkl(G) : GDVRKALGPKGRDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYP 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1a49(A) : LEAVRMQHLIAREAEAAMFHRKLFEELARSSSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNHQTARQAHLYRGIFPVVCKDPVQEAWAEDVDLRVN 
         :                                                                                                                          
 1pkl(G) : NEVVQYMARICLEAQSALNEYVFFNSIKKLQHIPMSADEAVCSSAVNSVYETKAKAMVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFF-DADKLGHDEGKEHRVA 
           ________________________________________________________________________________________________________________________ 

           ________________________________________                                                                                 
 1a49(A) : LAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP                                                                                 
         :                                                                                                                          
 1pkl(G) : AGVEFAKSKGYVQTGDYCVVIHADHKVKGYANQTRILLVE                                                                                 
           ________________________________________                                                                                 

Morph
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Status: Initialising

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		45.8
Translation
(A) 		-1.0
Closure
(%) 		100.0
Bending Residues
( green ) 		  116 - 117
  218 - 219
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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