DynDom - Protein Domain Motions

Pyruvate Kinase, M2 Isozyme

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Pyruvate Kinase, M2 Isozyme
Conformer 1 (PDB)	1zjh (A)
Conformer 2 (PDB)	2vgf (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	404	1.01	26 - 114 177 - 178 215 - 527
2	98	0.94	115 - 176 179 - 214

Sequence

`___________________________________________________________________________________________________114__________________` `1zjh(A) : **********TFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVE` `:` `2vgf(A) : QQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVE` `___________________________________________________________________________________________________158__________________` `_________________________________________176___________________________________214______________________________________` `1zjh(A) : LKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHE` `:` `2vgf(A) : LVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAA` `_________________________________________220___________________________________258______________________________________` `________________________________________________________________________________________________________________________` `1zjh(A) : VRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLE` `:` `2vgf(A) : VRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKPRPMRAETSDVANAVLDGADCIMLSGETAKGNFPVE` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1zjh(A) : AVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFA` `:` `2vgf(A) : AVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFG` `________________________________________________________________________________________________________________________` `______________________________________` `1zjh(A) : MNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP` `:` `2vgf(A) : IESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSI` `______________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	17.5
Translation (A)	0.1
Closure (%)	96.3
Bending Residues ( green )	114 - 115 176 - 179 214 - 215
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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