DynDom - Protein Domain Motions

Sucrose Isomerase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Sucrose Isomerase
Conformer 1 (PDB)	2pwe (A)
Conformer 2 (PDB)	4h2c (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	306	0.38	5 - 55 73 - 74 77 - 98 194 - 196 201 - 201 253 - 254 277 - 284 295 - 324 328 - 373 383 - 387 419 - 554
2	191	0.48	56 - 72 75 - 76 99 - 193 197 - 200 202 - 252 255 - 276
3	53	0.34	285 - 294 325 - 327 374 - 382 388 - 418

Sequence

`____________________________________________________55______________71________________________97________________________` `2pwe(A) : PGAPWWKSAVFYQVYPRSFKDTNGDGIGDFKGLTEKLDYLKGLGIDAIWINPHYASPNTDNGYDISDYREVMKEYGTMEDFDRLMAELKKRGMRLMVDVVINHSSDQHEWFKSSRASKDN` `:` `4h2c(A) : *GAPWWKSAVFYQVYPRSFKDTNGDGIGDFKGLTEKLDYLKGLGIDAIWINPHYASPNTDNGYDISDYREVMKEYGTMEDFDRLMAELKKRGMRLMVDVVINHSSDQHEWFKSSRASKDN` `____________________________________________________55______________71________________________97________________________` `_____________________________________________________________________193________________________________________________` `2pwe(A) : PYRDYYFWRDGKDGHEPNNYPSFFGGSAWEKDPVTGQYYLHYFGRQQPDLNWDTPKLREELYAMLRFWLDKGVSGMRFDTVATYSKTPGFPDLTPEQMKNFAEAYTQGPNLHRYLQEMHE` `:` `4h2c(A) : PYRDYYFWRDGKDGHEPNNYPSFFGGSAWEKDPVTGQYYLHYFGRQQPDLNWDTPKLREELYAMLRFWLDKGVSGMRFDTVATYSKTPGFPDLTPEQMKNFAEAYTQGPNLHRYLQEMHE` `_____________________________________________________________________193________________________________________________` `________252_____________________276_____284__289________________________________324_____________________________________` `2pwe(A) : KVFDHYDAVTAGQIFGAPLNQVPLFIDSRRKELDMAFTFDLIRYDRALDRWHTIPRTLADFRQTIDKVDAIAGEYGWNTFFLGNHDNPRAVSHFGDDRPQWREASAKALATVTLTQRGTP` `:` `4h2c(A) : KVFDHYDAVTAGEIFGAPLNQVPLFIDSRRKELDMAFTFDLICYDRALDRWHTIPRTLADFRQTIDKVDAIAGEYGWNTFFLGNHDNPRAVSHFGDDRPQWREASAKALATVTLTQRGTP` `________252_____________________276_____284__289________________________________324_____________________________________` `_________373______382_________________________________418_______________________________________________________________` `2pwe(A) : FIFQGDELGMTNYPFKTLQDFDDIEVKGFFQDYVETGKATAEELLTNVALTSRDNARTPFQWDDSANAGFTTGKPWLKVNPNYTEINAAREIGDPKSVYSFYRNLISIRHETPALSTGSY` `:` `4h2c(A) : FIFQGDELGMTNYPFKTLQDFDDIEVKGFFQDYVETGKATAEELLTNVALTSRDNARTPFQWDDSANAGFTTGKPWLKVNPNYTEINAAREIGDPKSVYSFYRNLISIRHETPALSTGSY` `_________373______382_________________________________418_______________________________________________________________` `____________________________________________________________________________` `2pwe(A) : RDIDPSNADVYAYTRSQDGETYLVVVNFKAEPRSFTLPDGMHIAETLIESSSPAAPAAGAASLELQPWQSGIYKVK` `:` `4h2c(A) : RDIDPSNADVYAYTRSQDGETYLVVVNFKAEPRSFTLPDGMHIAETLIESSSPAAPAAGAASLELQPWQSGIYKVK` `____________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	10.0
Translation (A)	0.6
Closure (%)	88.7
Bending Residues ( green )	55 - 56 71 - 77 97 - 99 193 - 202 252 - 255 276 - 280
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	5.4
Translation (A)	0.4
Closure (%)	97.9
Bending Residues ( green )	284 - 285 289 - 297 324 - 328 373 - 374 382 - 388 418 - 419
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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