Thioredoxin Glutathione Reductase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Thioredoxin Glutathione Reductase
  Conformer 1
(PDB) 		4la1 (A)
  Conformer 2
(PDB) 		3h4k (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 328 0.57   115 - 118   139 - 149   151 - 151   153 - 170   178 - 185   193 - 196   204 - 206   261 - 275   278 - 334   339 - 396   399 - 406   424 - 427   435 - 447   450 - 450   454 - 454   465 - 503   505 - 514   519 - 591
2 254 0.67   10 - 114   119 - 138   150 - 150   152 - 152   171 - 177   186 - 192   197 - 203   207 - 260   276 - 277   335 - 338   397 - 398   407 - 423   428 - 434   448 - 449   451 - 453   455 - 464   504 - 504   515 - 518

Sequence


           __________________________________________________________________________________________________________114_118_______ 
 4la1(A) : **SQWLQRTIESAAVIVFSKTTCPFCKKLKDVLAEAKIKHATIELDQLSNGSVIQKALSNFSKIETVPQMFVRGKFIGDSKAVLNYHNNNQLQAIVNENKYDYDLIIIGGGSGGLAAGKE 
         :                                                                                                                          
 3h4k(A) : GTSQWLRKTVDSAAVILFSKTTCPYCKKVKDVLAEAKIKHATIELDQLSNGSAIQKCLASFSKIETVPQMFVRGKFIGDSQTVLKYYSNDELAGIVNESKYDYDLIVIGGGSGGLAAGKE 
           __________________________________________________________________________________________________________114_118_______ 

           __________138________149__________________170____177_____185____192_196____203__________________________________________ 
 4la1(A) : AAKYGAKIAVLDYVEPTPMGTTWGLGGTCVNVGCIPKKLMHQAGLLSHSLEDAQHFGWSLDKSEISHDWSTMVEGVQSHIGSLNWGYKVSLRDNAVTYLNARGMLLSPHEVQITEKNKKV 
         :                                                                                                                          
 3h4k(A) : AAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLMHQAGLLSHALEDAEHFGWSLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQVTYLNAKGRLISPHEVQITDKNQKV 
           __________138________149__________________170____177_____185____192_196____203__________________________________________ 

           ____________260____________275________________________________________________________334_338___________________________ 
 4la1(A) : STITGNKIILATGERPKYPEIPGAIEYGITSDDLFSLPYFPGKTLVVGASYVALKCAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYMENHGVKFAKLCVPDEITQLKPVDTENNKP 
         :                                                                                                                          
 3h4k(A) : STITGNKIILATGERPKYPEIPGAVEYGITSDDLFSLPYFPGKTLVIGASYVALECAGFLASLGGDVTVMVRSILLRGFDQQMAEKVGDYMENHGVKFAKLCVPDEIKQLKVVDTENNKP 
           ____________260____________275________________________________________________________334_338___________________________ 

           ____________________________396________________________423_427____434_________446____453________464_____________________ 
 4la1(A) : GLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSKLNCEAVGVKLDKNGRVVCSDDEQTTVSNIYAIGDINAGKPQLTPVAIHAGRYLARRLFAGATELTDYSNVATTVFTPLEYGACGLS 
         :                                                                                                                          
 3h4k(A) : GLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSKVLCETVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFAGATELTDYSNVATTVFTPLEYGACGLS 
           ____________________________396________________________423_427____434_________446____453________464_____________________ 

           _______________503________514_518___________________________________________________________________________             
 4la1(A) : EEDAIEKYGDNDIEVYHSHFKPLEWTVAHREDNVCYMKLVCRISDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKEDFDRTIGIHPTCSETFTTLHVTKRSGGSAAV             
         :                                                                                                                          
 3h4k(A) : EEDAIEKYGDKDIEVYHSNFKPLEWTVAHREDNVCYMKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHPTCSETFTTLHVTKKSGVSPIV             
           _______________503________514_518___________________________________________________________________________             

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Status: Initialising

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		4.1
Translation
(A) 		0.3
Closure
(%) 		37.7
Bending Residues
( green ) 		  114 - 115
  118 - 123
  138 - 139
  149 - 153
  170 - 171
  177 - 178
  185 - 186
  192 - 193
  196 - 197
  203 - 204
  206 - 207
  260 - 261
  275 - 278
  334 - 335
  338 - 339
  396 - 407
  423 - 424
  427 - 428
  434 - 435
  446 - 451
  453 - 455
  464 - 467
  503 - 505
  514 - 516
  518 - 519
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

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