Tight Junction Protein Zo-1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Tight Junction Protein Zo-1
  Conformer 1
(PDB) 		3tsw (A)
  Conformer 2
(PDB) 		3lh5 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 145 0.67   642 - 798   801 - 801
2 85 1.79   518 - 641   799 - 800

Sequence


           ________________________________________________________________________________________________________________________ 
 3tsw(A) : MILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGL 
         :                                                                                                                          
 3lh5(A) : ****************************************************************************************************GDSFYIRTHFEYEKESPYGL 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________________________641___________________________________________________ 
 3tsw(A) : SFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQ----kFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKS----------iIRLHTIK 
         :                                                                                                                          
 3lh5(A) : SFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQgIIRLHTIK 
           __________________________________________________________________641___________________________________________________ 

           ___________________________________________________________________________________________________797______             
 3tsw(A) : QIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEG             
         :                                                                                                                          
 3lh5(A) : QIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEG             
           ___________________________________________________________________________________________________797______             

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		19.2
Translation
(A) 		0.8
Closure
(%) 		87.7
Bending Residues
( green ) 		  641 - 643
  797 - 801
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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