DynDom - Protein Domain Motions

Two-Component System Sensor Histidine Kinase/response

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Two-Component System Sensor Histidine Kinase/response
Conformer 1 (PDB)	4a2l (B)
Conformer 2 (PDB)	4a2m (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	424	0.61	30 - 337 662 - 781
2	314	0.87	338 - 661

Sequence

`________________________________________________________________________________________________________________________` `4a2l(B) : QITFSYISINEGLSQSTVFSIDQDKRGNMWFATYDGVNKYDGYAFTVYQHNEDDPNSIANDISRIVKTDSQGRVWIGTRDGLSRYDEEKDIFQNFFYEKNGKHLQVNGIEEISPEQLLIS` `:` `4a2m(B) : QITFSYISINEGLSQSTVFSIDQDKRGNMWFATYDGVNKYDGYAFTVYQHNEDDPNSIANDISRIVKTDSQGRVWIGTRDGLSRYDEEKDIFQNFFYEKNGKHLQVNGIEEISPEQLLIS` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `4a2l(B) : TPEGLIMFDIKESKFIDDSFSTAMHKTIASTLYRQGDQIYIGTSTDGLYTYSITQKTFEKVIPgTKQIQAILQQSPTRIWVATEGAGLFLINPKTKEIKNYLHSPSNPKSISSNYIRSLA` `:` `4a2m(B) : TPEGLIMFDIKESKFIDDSFSTAMHKTIASTLYRQGDQIYIGTSTDGLYTYSITQKTFEKVI--tKQIQAILQQSPTRIWVATEGAGLFLINPKTKEIKNYLHSPSNPKSISSNYIRSLA` `________________________________________________________________________________________________________________________` `_________________________________________________________________337____________________________________________________` `4a2l(B) : MDSQNRLWIGTFNDLNIYHEGTDSFASYSSNPVENGSLSQRSVRSIFMDSQGGMWLGTYFGGLNYYHPIRNRFKNIRNIPYKNSLSDNVVSCIVEDKDKNLWIGTNDGGLNLYNPITQRF` `:` `4a2m(B) : MDSQNRLWIGTFNDLNIYHEGTDSFASYSSNPVENGSLSQRSVRSIFMDSQGGMWLGTYFGGLNYYHPIRNRFKNIRNIPYKNSLSDNVVSCIVEDKDKNLWIGTNDGGLNLYNPITQRF` `_________________________________________________________________337____________________________________________________` `________________________________________________________________________________________________________________________` `4a2l(B) : TSYTL--------sNNIKAVYVDEKKSLVYIGTHAGGLSILHRNSGQVENFNQRNSQLVNENVYAILPDGEGNLWLGTLSALVRFNPEQRSFTTIEKEKDGTPVVSKQITTLFRDSHKRL` `:` `4a2m(B) : TSYTLQEDaRGIGSNNIKAVYVDEKKSLVYIGTHAGGLSILHRNSGQVENFNQRNSQLVNENVYAILPDGEGNLWLGTLSALVRFNPEQRSFTTIEKEKDGTPVVSKQITTLFRDSHKRL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `4a2l(B) : WIGGEEGLSVFKQEGLDIQKASILPVSNVTKLFTNCIYEASNGIIWVGTREGFYCFNEKDKQIKRYNTTNGLPNNVVYGILEDSFGRLWLSTNRGISCFNPETEKFRNFTESDGLQSNQF` `:` `4a2m(B) : WIGGEEGLSVFKQEGLDIQKASILPVSNVTKLFTNCIYEASNGIIWVGTREGFYCFNEKDKQIKRYNTTNGLPNNVVYGILEDSFGRLWLSTNRGISCFNPETEKFRNFTESDGLQSNQF` `________________________________________________________________________________________________________________________` `__________________________660___________________________________________________________________________________________` `4a2l(B) : NTASYCRTSVGQMYFGGINGITTFRPELLLDNPYTPPVVITKLQLFNKVVRPDDETGILTKNISETKSITLKSWQTAFSIEFVVSNYISGQHNTFAYKLEGYDKEWYYLTDSRTVSYSNL` `:` `4a2m(B) : NTASYCRTSVGQMYFGGINGITTFRPELLLDNPYTPPVVITKLQLFNKVVRPDDETGILTKNISETKSITLKSWQTAFSIEFVVSNYISGQHNTFAYKLEGYDKEWYYLTDSRTVSYSNL` `__________________________660___________________________________________________________________________________________` `________________________________` `4a2l(B) : PQGTYQFLVKAANSDGKWNPIPTALEIIVLPI` `:` `4a2m(B) : PQGTYQFLVKAANSDGKWNPIPTALEIIVLPI` `________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	19.3
Translation (A)	3.6
Closure (%)	99.7
Bending Residues ( green )	337 - 342 660 - 663
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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