Epidermal Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Epidermal Growth Factor Receptor
  Conformer 1
(PDB)
1nql (A)
  Conformer 2
(PDB)
1m6b (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 93 1.87   207 - 244   253 - 307   309 - 309
2 169 2.85   34 - 206
3 276 1.73   245 - 252   308 - 308   310 - 579

Sequence


           ________________________________________________________________________________________________________________________ 
 1nql(A) : EKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT-GLKELPMRNLQEILH 
         :                                                                                                                          
 1m6b(A) : **************************AVCPrCEVVMGNLEIVLTGHNADLSFLQWVREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILS 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________________________________________206___________________________________ 
 1nql(A) : GAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCP 
         :                                                                                                                          
 1m6b(A) : GGVYIEKNDKLCHMDTIDWRDIVRD---RDAEIVVKDNGRSCPPCHEVC-KGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCP 
           __________________________________________________________________________________206___________________________________ 

           244_____252___________________________________________________306_______________________________________________________ 
 1nql(A) : PLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIG-EFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHT 
         :                                                                                                                          
 1m6b(A) : QPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVV-DQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQ---TVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKI 
           244_____252___________________________________________________305_______________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1nql(A) : PPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVV-SLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLF-GTSGQKTKIISNRGENSCKAT 
         :                                                                                                                          
 1m6b(A) : PALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAE 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1nql(A) : GQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCKLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHP 
         :                                                                                                                          
 1m6b(A) : GKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGP***************** 
           ________________________________________________________________________________________________________________________ 

           ________________                                                                                                         
 1nql(A) : NCTYGCTGPGLEGCPT                                                                                                         
         :                                                                                                                          
 1m6b(A) : ****************                                                                                                         
           ________________                                                                                                         

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
38.2
Translation
(A)
0.6
Closure
(%)
97.9
Bending Residues
( green )
  206 - 207
Bending Region Analysis
Property Value
Fixed Domain
( blue )
1
Moving Domain
( yellow )
3
Rotation Angle
(deg)
24.3
Translation
(A)
-1.0
Closure
(%)
98.8
Bending Residues
( green )
  244 - 245
  252 - 253
  306 - 310
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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