DynDom - Protein Domain Motions

Leukotriene A-4 Hydrolase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Leukotriene A-4 Hydrolase
Conformer 1 (PDB)	2xpy (A)
Conformer 2 (PDB)	2xq0 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	455	0.9	42 - 305 314 - 510 596 - 596
2	166	0.89	306 - 313 511 - 595 597 - 669

Sequence

`________________________________________________________________________________________________________________________` `2xpy(A) : MLPLSIEQRRPSRSPEYDQSTLSNYKDFAVLHTDLNLSVSFEKSAISGSVTFQLKKLHEGKNKSDELHLDTSYLDVQEVHIDGSKADFQIEQRKEPLGSRLVINNASCNDNFTLNIQFRT` `:` `2xq0(A) : MLPLSIEQRRPSRSPEYDQSTLSNYKDFAVLHTDLNLSVSFEKSAISGSVTFQLKKLH---nKSDELHLDTSYLDVQEVHIDGSKADFQIEQRKEPLGSRLVINNASCNDNFTLNIQFRT` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2xpy(A) : TDKCTALQWLNSKQTKGGKPYVFSQLEAIHARSLFPCFDTPSVKSTFTASIESPLPVVFSGIRIEdTNIYRFEQKVPIPAYLIGIASGDLSSAPIGPRSTVYTEPFRLKDCQWEFENDVE` `:` `2xq0(A) : TDKCTALQWLNSKQTKGGKPYVFSQLEAIHARSLFPCFDTPSVKSTFTASIESPLPVVFSGIRIEDtNIYRFEQKVPIPAYLIGIASGDLSSAPIGPRSTVYTEPFRLKDCQWEFENDVE` `________________________________________________________________________________________________________________________` `___________________305_____313__________________________________________________________________________________________` `2xpy(A) : KFIQTAEKIIFEYEWGTYDILVNVDSYPYGGMESPNMTFATPTLIAHDRSNIDVIAHELAHSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDLQNSIDSMKD` `:` `2xq0(A) : KFIQTAEKIIFEYEWGTYDILVNVDSYPYGGMESPNMTFATPTLLAHDRSNIDVIAHELAHSWSGNLVTNCSWNHFWLNEGWTVYLERRIIGAIHGEPTRHFSALIGWSDLQNSIDSMKD` `___________________305_____313__________________________________________________________________________________________` `________________________________________________________________________________________________________510_____________` `2xpy(A) : PERFSTLVQNLNDNTDPDDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPEKKEILDSVDWETWLYKPGMPPRPHFITALADNVYQLADKWVEM` `:` `2xq0(A) : PERFSTLVQNLNDNTDPDDAFSTVPYEKGFNLLFHLETILGGKAEFDPFIRHYFKKFAKKSLDTFQFLDTLYEFYPEKKEILDSVDWETWLYKPGMPPRPHFITALADNVYQLADKWVEM` `________________________________________________________________________________________________________510_____________` `_____________________________________________________________________595________________________________________________` `2xpy(A) : AQHLKTTEDFRSEFNAIDIKDFNSNQLVLFLETLTQNGHSNKKPKDFDWAKFPVASRALLDIYQDNIVKSQNAEVVFKMFKFQIFAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNSVDR` `:` `2xq0(A) : AQHLKTTEDFRSEFNAIDIKDFNSNQLVLFLETLTQNGHSNKKPKDFDWAKFPVASRALLDIYQDNIVKSQNAEVVFKMFKFQIFAKLQEEYKHLADWLGTVGRMKFVRPGYRLLNSVDR` `_____________________________________________________________________595________________________________________________` `____________________________` `2xpy(A) : RLALATFDKFKDTYHPICKALVKQDLGL` `:` `2xq0(A) : RLALATFDKFKDTYHPICKALVKQDLKL` `____________________________`

Morph

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Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	15.1
Translation (A)	0.3
Closure (%)	72.7
Bending Residues ( green )	305 - 306 313 - 314 510 - 511 595 - 597
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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