DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor Subtype 1
Conformer 1 (PDB)	1ewk (B)
Conformer 2 (PDB)	2e4u (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	263	1.95	37 - 208 345 - 478
2	164	1.74	209 - 344 479 - 510

Sequence

`________________________________________________________________________________________________________________________` `1ewk(B) : QRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRk---P--IAGVIGPGSSSVAIQVQNLLQL` `:` `2e4u(B) : FMRREIKIEGDLVLGGLFPINEKGTGTE----ECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLiPLLIAGVIGGSYSSVSIQVANLLRL` `________________________________________________________________________________________________________________________` `____________________________208_________________________________________________________________________________________` `1ewk(B) : FDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVR` `:` `2e4u(B) : FQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQK-PNARVVVLFMRSDDSR` `____________________________194_________________________________________________________________________________________` `____________________________________________344_________________________________________________________________________` `1ewk(B) : GLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEE-NYVQDSKMGFVINA` `:` `2e4u(B) : ELIAAANR--VNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSL----------QqVCDKHLAIDSSNYEQESKIMFVVNA` `____________________________________________327_________________________________________________________________________` `__________________________________________________________________478___________________________________________________` `1ewk(B) : IYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLL-DFLIKSSFVGV----SGEE--VWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGV-LNIDDYKI*************` `:` `2e4u(B) : VYAMAHALHKMQRTLCPQTTKLCDAMKILDGKKLYKEYLLKIQFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQT-GGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAP` `__________________________________________________________________465___________________________________________________` `____________________________________________________` `1ewk(B) : **************************************************` `:` `2e4u(B) : NEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPE` `____________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	35.5
Translation (A)	0.3
Closure (%)	100.0
Bending Residues ( green )	208 - 209 344 - 345 478 - 479
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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