Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Metabotropic Glutamate Receptor Subtype 1
  Conformer 1
(PDB) 		1ewk (B)
  Conformer 2
(PDB) 		3lmk (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 267 1.23   37 - 208   344 - 474   476 - 476
2 166 1.08   209 - 343   475 - 475   477 - 506

Sequence


           ________________________________________________________________________________________________________________________ 
 1ewk(B) : QRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIR-kPIAGVIGPGSSSVAIQVQNLLQLFDIPQ 
         :                                                                                                                          
 3lmk(A) : RRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDkPIVGVIGPGSSSVAIQVQNLLQLFNIPQ 
           ________________________________________________________________________________________________________________________ 

           _______________________208______________________________________________________________________________________________ 
 1ewk(B) : IAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSA 
         :                                                                                                                          
 3lmk(A) : IAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGISIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMA 
           _______________________195______________________________________________________________________________________________ 

           ______________________________________343_______________________________________________________________________________ 
 1ewk(B) : MRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAH 
         :                                                                                                                          
 3lmk(A) : MRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGn--------KTCNSSLTLKTHHVQDSKMGFVINAIYSMAY 
           ______________________________________330_______________________________________________________________________________ 

           _________________________________________________474______________________________________                               
 1ewk(B) : GLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKI                               
         :                                                                                                                          
 3lmk(A) : GLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD****                               
           _________________________________________________461______________________________________                               

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		32.8
Translation
(A) 		0.0
Closure
(%) 		99.9
Bending Residues
( green ) 		  208 - 209
  343 - 346
  474 - 479
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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