Non-Ribosomal Peptide Synthetase Modules

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Non-Ribosomal Peptide Synthetase Modules
  Conformer 1
(PDB) 		7c1h (A)
  Conformer 2
(PDB) 		7c1r (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 213 1.8   178 - 277   279 - 279   281 - 282   287 - 352   371 - 429
2 192 1.18   10 - 177   278 - 278   280 - 280   283 - 286   353 - 370

Sequence


           ________________________________________________________________________________________________________________________ 
 7c1h(A) : ********STTYALSAAQTEIWLAQQLYPDSPVYNIAQYTVIEGVIEPAVFEAALRQVIDEADTLRLQFIDSDDGLRQRIGTPAWSMPVLDLTAQADPQAAAQAWMRADYQQPVNLTQGP 
         :                                                                                                                          
 7c1r(A) : SHMDASVMSTTYALSAAQTEIWLAQQLYPDSPVYNIAQYTVIEGVIEPAVFEAALRQVIDEADTLRLQFIDSDDGLRQRIGTPAWSMPVLDLTAQADPQAAAQAWMRADYQQPVNLTQGP 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________177_____________________________________________________________ 
 7c1h(A) : LFCYALLKVAPAQWMWYQRYHHIMMDGYGRYLIAQRVAYVYSALCEGTTPAECDFGSILQLLESDAQYQISAQRAQDEAYWLKHCANWSEPATLAS-------qRLRQTTYLAIQA-dAR 
         :                                                                                                                          
 7c1r(A) : LFCYALLKVAPAQWMWYQRYHVIMMDGYGAYLIAQRVAYVYSALCEGTTPAECDFGSILQLLESDAQYQISAQRAQDEAYWLKHCANWSEPATLASRSAPVLQQRLRQTTYLAIQApDAR 
           ________________________________________________________177_____________________________________________________________ 

           ____________________________274_________286__________________________________________________________347________________ 
 7c1h(A) : RLAQFMTAAMAAYLYRFTGEQDVVLGLPVKVRFGADRHIPGMKSNTLPLRLTMRPGMNLSSLMQQAAQEMQSGLRHQRYPSEALRRQLGMP--qRLFGTTVNVMPFDLDLSFGGYSATNH 
         :                                                                                                                          
 7c1r(A) : RLAQFMTAAMAAYLYRFTGEQDVVLGLPVKVRFGADRHIPGMKSNTLPLRLTMRPGMNLSSLMQQAAQEMQSGLRHQRYPSEALRRQLGMPSGQRLFGTTVNVMPFDLDLSFGGYSATNH 
           ____________________________274_________286__________________________________________________________347________________ 

           ____370_____________________________________________________________                                                     
 7c1h(A) : NLLNGPAEDLMLGVYWTPGSHQLRIDFDANPACYTPEGLGAHQRRFIRFMQVLAADATQPIDSIDLLD                                                     
         :                                                                                                                          
 7c1r(A) : NLLNGPAEDLMLGVYWTPGSHQLRIDFDANPACYTPEGLGAHQRRFIRFMQVLAADATQPIDSIDLLD                                                     
           ____370_____________________________________________________________                                                     

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		12.7
Translation
(A) 		1.6
Closure
(%) 		92.5
Bending Residues
( green ) 		  177 - 178
  274 - 283
  286 - 287
  347 - 353
  370 - 371
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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