Possible Thiamine Biosynthesis Enzyme

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Possible Thiamine Biosynthesis Enzyme
  Conformer 1
(PDB) 		2x7q (A)
  Conformer 2
(PDB) 		2x7p (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 202 0.54   3 - 86   184 - 301
2 95 0.56   87 - 183

Sequence


           ____________________________________________________________________________________86__________________________________ 
 2x7q(A) : LPTLKVAYIPEHFSTPLFFAQQQGYYKAHDLSIEFVKVPEGSGRLINLLNSNEVDIAIGLTEAFIADIAKGNENIHVLDTYVKSPLLWAVSTGSNRDDVTDAKQLKRIGVSRIGSGSYVs 
         :                                                                                                                          
 2x7p(A) : LPTLKVAYIPEHFSTPLFFAQQQGYYKAHDLSIEFVKVPEGSGRLINLLNSNEVDIAIGLTEAFIADIAKGNENIHVLDTYVKSPLLWAVSTGSNRDDVTDAKQLKRIGVSRIGSGSYVs 
           ____________________________________________________________________________________86__________________________________ 

           __________________________________________________________183___________________________________________________________ 
 2x7q(A) : FVLAHQLGVPSFDQFQVLSNFKNLRDSVNLKDGVEGSDAFwEYFTSKKYYDNHEIKQIDQIYTPWSSWVVATSSDSLQAKSDVIKNFIDAVNQGIQYYNEHVDEAIEYISSNLDYSAEDA 
         :                                                                                                                          
 2x7p(A) : FVLAHQLGVPSFDQFQVLSNFKNLRDSVNLKDGVEGSDAFwEYFTSKKYYDNHEIKQIDQIYTPWSSWVVATSSDSLQAKSDVIKNFIDAVNQGIQYYNEHVDEAIEYISSNLDYSAEDA 
           __________________________________________________________183___________________________________________________________ 

           ________________________________________________________________                                                         
 2x7q(A) : KEWTKTVEFNSRIGKTPLDWDTIVVKTKDTLKLAGVLAESDDVILKRLNSNVKKTNLQLDGDLE                                                         
         :                                                                                                                          
 2x7p(A) : KEWTKTVEFNSRIGKTPLDWDTIVVKTKDTLKLAGVLAESDDVILKRLNSNVKKTNLQLDGDLE                                                         
           ________________________________________________________________                                                         

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		13.4
Translation
(A) 		-0.3
Closure
(%) 		62.0
Bending Residues
( green ) 		  86 - 87
  183 - 184
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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