Fibroblast Growth Factor Receptor 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Fibroblast Growth Factor Receptor 2
  Conformer 1
(PDB) 		2pvf (A)
  Conformer 2
(PDB) 		7vjl (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 168 1.37   544 - 547   568 - 763
2 88 0.76   470 - 543   548 - 567

Sequence


           __________________________________________________________________________543_547_________________567___________________ 
 2pvf(A) : ELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKP---vTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEs 
         :                                                                                                                          
 7vjl(B) : DLPLDPLWEFPRDRLVLGKPLG---fGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPg--- 
           __________________________________________________________________________529_533_________________553___________________ 

           ________________________________________________________________________________________________________________________ 
 2pvf(A) : YqMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDkKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 
         :                                                                                                                          
 7vjl(B) : -PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFG-----------------pVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLR 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________                                                                       
 2pvf(A) : EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT**                                                                       
         :                                                                                                                          
 7vjl(B) : EGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEE                                                                       
           __________________________________________________                                                                       

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		19.1
Translation
(A) 		-0.1
Closure
(%) 		98.1
Bending Residues
( green ) 		  543 - 544
  547 - 548
  567 - 568
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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