Homoserine Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Homoserine Dehydrogenase
  Conformer 1
(PDB) 		2ejw (A)
  Conformer 2
(PDB) 		6a0s (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 275 0.39   3 - 151   186 - 216   235 - 329
2 45 0.72   152 - 178   217 - 234

Sequence


           ________________________________________________________________________________________________________________________ 
 2ejw(A) : MEALKIALLGGGTVGSAFYNLVLERAEELSAFGVVPRFLGVLVRDPRKPRAIPQELLRAEPFDLLEADLVVEAMGGVEAPLRLVLPALEAGIPLITANKALLAEAWESLRPFAEEGLIYH 
         :                                                                                                                          
 6a0s(A) : MEALKIALLGGGTVGSAFYNLVLERAEELSAFGVVPRFLGVLVRDPRKPRAIPQELLRAEPFDLLEADLVVEAMGGVEAPLRLVLPALEAGIPLITANKALLAEAWESLRPFAEEGLIYH 
           ________________________________________________________________________________________________________________________ 

           ____________________________151________________________178___________________________________216_______________234______ 
 2ejw(A) : EASVMAGTPALSFLETLRGSELLELHGILNGTTLYILQEMEKGRTYAEALLEAQRLGYAEADPTLDVEGIDAAHKLTLLARLLVDPGFPFAEVEAQGIARLTPEVLQKAEARGERVRLVA 
         :                                                                                                                          
 6a0s(A) : EASVMAGTPALSFLETLRGSELLELHGILNGTTLYILQEMEKGRTYAEALLEAQRLGYAEADPTLDVEGIDAAHKLTLLARLLVDPGFPFAEVEAQGIARLTPEVLQKAEARGERVRLVA 
           ____________________________151________________________178___________________________________216_______________234______ 

           ___________________________________________________________________________________________                              
 2ejw(A) : SLFGEGGRWRAAVAPRRLPQDHPLARARGNALWVRARPLGEAFVTGPGAGGGATASGLFADLLRFLSGAPGHLPAPRARPPLEEGSPWPGV                              
         :                                                                                                                          
 6a0s(A) : SLFGEGGRWRAAVAPRRLPQDHPLARARGNALWVRARPLGEAFVTGPGAGGGATASGLFADLLRFLSGAPGHLPAPRARPPLEEGSPWPGV                              
           ___________________________________________________________________________________________                              

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		7.5
Translation
(A) 		-0.2
Closure
(%) 		93.2
Bending Residues
( green ) 		  151 - 152
  178 - 186
  216 - 218
  234 - 235
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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