DynDom - Protein Domain Motions

Insulin-Like Growth Factor 1 Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Insulin-Like Growth Factor 1 Receptor
Conformer 1 (PDB)	6jk8 (B)
Conformer 2 (PDB)	7v3p (B)
Window Length	7
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	762	7.1	34 - 665 778 - 925
2	29	17.46	670 - 777

Sequence

`________________________________________________________________________________________________________________________` `6jk8(B) : EICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKArSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLS` `:` `7v3p(B) : EICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKArSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLS` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6jk8(B) : TVDWSLILDAVSNNYIVGNKPPKECGDLCPGcEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRD` `:` `7v3p(B) : TVDWSLILDAVSNNYIVGNKPPKECGDLCPGcEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRD` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6jk8(B) : FCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLS` `:` `7v3p(B) : FCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLS` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6jk8(B) : FLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDL` `:` `7v3p(B) : FLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6jk8(B) : ISFTVYYKEAPFKNVTEYn--SWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIV` `:` `7v3p(B) : ISFTVYYKEAPFKNVTEYDGQsWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIV` `________________________________________________________________________________________________________________________` `______________663_____________________________________________777_______________________________________________________` `6jk8(B) : RWQRQPQDGYLYRHNYCSKDKIPIRK--------eKQAEKEEAEYRKVFENFLHNSI-----eYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGA` `:` `7v3p(B) : RWQRQPQDGYLYRHNYCSKDKIPIRKcACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPeYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGA` `______________633_____________________________________________746_______________________________________________________` `________________________________________________________________________________________________` `6jk8(B) : DDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAK` `:` `7v3p(B) : DDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAK` `________________________________________________________________________________________________`

Morph

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Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	101.7
Translation (A)	22.4
Closure (%)	98.2
Bending Residues ( green )	663 - 670 777 - 778
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

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