DynDom - Protein Domain Motions

Pyruvate Kinase Isozymes M1/m2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Pyruvate Kinase Isozymes M1/m2
Conformer 1 (PDB)	4fxj (A)
Conformer 2 (PDB)	3srh (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	395	1.12	30 - 117 220 - 529
2	99	0.77	118 - 219

Sequence

`____________________________________________________________________________________________________116_________________` `4fxj(A) : **************EHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKG---aEVE` `:` `3srh(A) : QTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVE` `____________________________________________________________________________________________________115_________________` `__________________________________________________________________________________218___________________________________` `4fxj(A) : LKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHE` `:` `3srh(A) : LKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHE` `__________________________________________________________________________________217___________________________________` `________________________________________________________________________________________________________________________` `4fxj(A) : VRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLE` `:` `3srh(A) : VRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLE` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `4fxj(A) : AVRMQNLIAREAEAAIYHLQLFEELRRLAP---dPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFA` `:` `3srh(A) : AVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFA` `________________________________________________________________________________________________________________________` `______________________________________` `4fxj(A) : MNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP` `:` `3srh(A) : MNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP` `______________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	23.7
Translation (A)	0.0
Closure (%)	97.6
Bending Residues ( green )	116 - 118 218 - 221
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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