Trypanothione Reductase (E.C.1.6.4.8)

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Trypanothione Reductase (E.C.1.6.4.8)
  Conformer 1
(PDB)
1typ (B)
  Conformer 2
(PDB)
2tpr (B)
  Window Length 11
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 277 0.35   56 - 95   159 - 285   366 - 475
2 190 0.37   9 - 55   96 - 158   286 - 365

Sequence


           ____________________________________________________55______________________________________95__________________________ 
 1typ(B) : SRAYDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGTCVNVGCVPKKLMVTGANYMDTIRESAGFGWELDRESVRPNWKALIAAKNKAVSGINDSYEGMFADTEGLT 
         :                                                                                                                          
 2tpr(B) : SRAYDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGTCVNVGCVPKKLMVTGANYMDTIRESAGFGWELDRESVRPNWKALIAAKNKAVSGINDSYEGMFADTEGLT 
           ____________________________________________________54______________________________________94__________________________ 

           __________________________________158___________________________________________________________________________________ 
 1typ(B) : FHQGWGALQDNHTVLVRESADPNSAVLETLDTEYILLATGSWPQHLGIEGDDLCITSNEAFYLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDLAYRGDMILRGFDSELRKQLTEQ 
         :                                                                                                                          
 2tpr(B) : FHQGFGALQDNHTVLVRESADPNSAVLETLDTEYILLATGSWPQHLGIEGDDLCITSNEAFYLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDLAYRGDMILRGFDSELRKQLTEQ 
           __________________________________157___________________________________________________________________________________ 

           _________________________________________285____________________________________________________________________________ 
 1typ(B) : LRANGINVRTHENPAKVTKNADGTRHVVFESGAEADYDVVMLAIGRVPRSQTLQLDKAGVEVAKNGAIKVDAYSKTNVDNIYAIGDVTDRVMLTPVAINEGAAFVDTVFANKPRATDHTK 
         :                                                                                                                          
 2tpr(B) : LRANGINVRTHENPAKVTKNADGTRHVVFESGAEADYDVVMLAIGRVPRSQTLQLEKAGVEVAKNGAIKVDAYSKTNVDNIYAIGDVTDRVMLTPVAINEGAAFVDTVFANKPRATDHTK 
           _________________________________________284____________________________________________________________________________ 

           _365____________________________________________________________________________________________________________________ 
 1typ(B) : VACAVFSIPPMGVCGYVEEDAAKKYDQVAVYESSFTPLMHNISGSTYKKFMVRIVTNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKISDFYNTIGVHPTSAEELCSMRTPAYFYQKG 
         :                                                                                                                          
 2tpr(B) : VACAVFSIPPMGVCGYVEEDAAKKYDQVAVYESSFTPLMHNISGSTYKKFMVRIVTNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKISDVYNTIGVHPTSAEELCSMRTPAYFYEKG 
           _364____________________________________________________________________________________________________________________ 

           ______                                                                                                                   
 1typ(B) : KRVEKI                                                                                                                   
         :                                                                                                                          
 2tpr(B) : KR****                                                                                                                   
           ______                                                                                                                   

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
2.8
Translation
(A)
-0.1
Closure
(%)
56.2
Bending Residues
( green )
  55 - 56
  95 - 96
  158 - 159
  285 - 286
  365 - 366
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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