DynDom - Protein Domain Motions

Two-Component System Sensor Histidine Kinase/response

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Two-Component System Sensor Histidine Kinase/response
Conformer 1 (PDB)	4a2l (A)
Conformer 2 (PDB)	4a2m (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	426	0.87	30 - 336 338 - 338 340 - 340 661 - 781
2	311	0.54	337 - 337 339 - 339 341 - 660

Sequence

`________________________________________________________________________________________________________________________` `4a2l(A) : QITFSYISINEGLSQSTVFSIDQDKRGNMWFATYDGVNKYDGYAFTVYQHNEDDPNSIANDISRIVKTDSQGRVWIGTRDGLSRYDEEKDIFQNFFYEKNGKHLQVNGIEEISPEQLLIS` `:` `4a2m(A) : QITFSYISINEGLSQSTVFSIDQDKRGNMWFATYDGVNKYDGYAFTVYQHNEDDPNSIANDISRIVKTDSQGRVWIGTRDGLSRYDEEKDIFQNFFYEKNGKHLQVNGIEEISPEQLLIS` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `4a2l(A) : TPEGLIMFDIKESKFIDDSFSTAMHKTIASTLYRQGDQIYIGTSTDGLYTYSITQKTFEKVItKQIQAILQQSPTRIWVATEGAGLFLINPKTKEIKNYLHSPSNPKSISSNYIRSLAMD` `:` `4a2m(A) : TPEGLIMFDIKESKFIDDSFSTAMHKTIASTLYRQGDQIYIGTSTDGLYTYSITQKTFEKVItKQIQAILQQSPTRIWVATEGAGLFLINPKTKEIKNYLHSPSNPKSISSNYIRSLAMD` `________________________________________________________________________________________________________________________` `______________________________________________________________336_______________________________________________________` `4a2l(A) : SQNRLWIGTFNDLNIYHEGTDSFASYSSNPVENGSLSQRSVRSIFMDSQGGMWLGTYFGGLNYYHPIRNRFKNIRNIPYKNSLSDNVVSCIVEDKDKNLWIGTNDGGLNLYNPITQRFTS` `:` `4a2m(A) : SQNRLWIGTFNDLNIYHEGTDSFASYSSNPVENGSLSQRSVRSIFMDSQGGMWLGTYFGGLNYYHPIRNRFKNIRNIPYKNSLSDNVVSCIVEDKDKNLWIGTNDGGLNLYNPITQRFTS` `______________________________________________________________336_______________________________________________________` `________________________________________________________________________________________________________________________` `4a2l(A) : YTLQgIGSNNIKAVYVDEKKSLVYIGTHAGGLSILHRNSGQVENFNQRNSQLVNENVYAILPDGEGNLWLGTLSALVRFNPEQRSFTTIEKEKDGTPVVSKQITTLFRDSHKRLWIGGEE` `:` `4a2m(A) : YTLQ-----nIKAVYVDEKKSLVYIGTHAGGLSILHRNSGQVENFNQRNSQLVNENVYAILPDGEGNLWLGTLSALVRFNPEQRSFTTIEKEKDGTPVVSKQITTLFRDSHKRLWIGGEE` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `4a2l(A) : GLSVFKQEGLDIQKASILPVSNVTKLFTNCIYEASNGIIWVGTREGFYCFNEKDKQIKRYNTTNGLPNNVVYGILEDSFGRLWLSTNRGISCFNPETEKFRNFTESDGLQSNQFNTASYC` `:` `4a2m(A) : GLSVFKQEGLDIQKASILPVSNVTKLFTNCIYEASNGIIWVGTREGFYCFNEKDKQIKRYNTTNGLPNNVVYGILEDSFGRLWLSTNRGISCFNPETEKFRNFTESDGLQSNQFNTASYC` `________________________________________________________________________________________________________________________` `__________________658___________________________________________________________________________________________________` `4a2l(A) : RTSVGQMYFGGINGITTFRPELLLDNPYTPPVVITKLQLFNKVVRPDDETGILTKNISETKSITLKSWQTAFSIEFVVSNYISGQHNTFAYKLEGYDKEWYYLTDSRTVSYSNLPQGTYQ` `:` `4a2m(A) : RTSVGQMYFGGINGITTFRPELLLDNPYTPPVVITKLQLFNKVVRPDDETGILTKNISETKSITLKSWQTAFSIEFVVSNYISGQHNTFAYKLEGYDKEWYYLTDSRTVSYSNLPQGTYQ` `__________________658___________________________________________________________________________________________________` `___________________________` `4a2l(A) : FLVKAANSDGKWNPIPTALEIIVLPIW` `:` `4a2m(A) : FLVKAANSDGKWNPIPTALEIIVLPI*` `___________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	18.6
Translation (A)	4.1
Closure (%)	99.3
Bending Residues ( green )	336 - 342 658 - 663
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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