DynDom - Protein Domain Motions

G Protein-Coupled Receptor Kinase 6

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	G Protein-Coupled Receptor Kinase 6
Conformer 1 (PDB)	3nyn (A)
Conformer 2 (PDB)	2acx (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	265	1.54	26 - 228 237 - 242 249 - 264 472 - 502 505 - 530
2	220	0.97	229 - 236 243 - 248 265 - 471 503 - 504

Sequence

`________________________________________________________________________________________________________________________` `3nyn(A) : ELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEV` `:` `2acx(A) : *****************KARkGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERNPIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRNLTQNFLSHTGPDLIPEV` `________________________________________________________________________________________________________________________` `_______________________________________________________________________________________________________227______236___24` `3nyn(A) : PRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV` `:` `2acx(A) : PRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKV` `_______________________________________________________________________________________________________227______236___24` `2___248_____________264_________________________________________________________________________________________________` `3nyn(A) : NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER` `:` `2acx(A) : NSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER` `2___248_____________264_________________________________________________________________________________________________` `______________________________________________________________________________________________________466_______________` `3nyn(A) : YTFSPDWWALGCLLYEMIAGQSPFQ---kKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIE` `:` `2acx(A) : YTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYC-------` `______________________________________________________________________________________________________466_______________` `__________________502_______________________________________________________` `3nyn(A) :` `QFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFS` `:` `2acx(A) :` `----------ePTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGS***********************` `__________________502_______________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	12.8
Translation (A)	0.2
Closure (%)	99.5
Bending Residues ( green )	227 - 231 236 - 237 242 - 243 248 - 249 264 - 265 466 - 496 502 - 505
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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