Interferon-Induced, Double-Stranded Rna- Activated Protein Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Interferon-Induced, Double-Stranded Rna- Activated Protein Kinase
  Conformer 1
(PDB) 		2a1a (B)
  Conformer 2
(PDB) 		2a19 (C)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 118 0.95   314 - 321   367 - 538
2 80 0.78   259 - 313   322 - 366

Sequence


           ________________________________________________________313_____321_________________________366_________________________ 
 2a1a(B) : GAHTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSsRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLA 
         :                                                                                                                          
 2a19(C) : **HTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETS---kTKCLFIQMEFCDKGTL---------------lA 
           ________________________________________________________313_____321_________________________366_________________________ 

           ________________________________________________________________________________________________________________________ 
 2a1a(B) : LELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRrSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEK 
         :                                                                                                                          
 2a19(C) : LELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLV----------------------------gKEVDLYALGLILAELL------------------gIISDIFDKKEK 
           ________________________________________________________________________________________________________________________ 

           _____________________________                                                                                            
 2a1a(B) : TLLQKLLSKKPEDRPNTSEILRTLTVWKK                                                                                            
         :                                                                                                                          
 2a19(C) : TLLQKLLSKKPEDRPNTSEILRTLTVWKK                                                                                            
           _____________________________                                                                                            

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		15.4
Translation
(A) 		-0.7
Closure
(%) 		62.9
Bending Residues
( green ) 		  313 - 314
  321 - 322
  366 - 367
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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