Isocitrate Dehydrogenase [Nadp]

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Isocitrate Dehydrogenase [Nadp]
  Conformer 1
(PDB) 		2qfx (A)
  Conformer 2
(PDB) 		2qfw (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 237 0.55   5 - 6   9 - 12   38 - 44   56 - 69   96 - 112   119 - 293   296 - 305   343 - 346   351 - 354
2 166 0.83   7 - 8   13 - 37   45 - 55   70 - 95   113 - 118   294 - 295   306 - 342   347 - 350   355 - 407

Sequence


           ____6____12_______________________37_____44_________55____________69________________________95______________112___118___ 
 2qfx(A) : FSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRL 
         :                                                                                                                          
 2qfw(A) : *SKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRL 
           ____6____12_______________________37_____44_________55____________69________________________95______________112___118___ 

           ________________________________________________________________________________________________________________________ 
 2qfx(A) : VPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKF 
         :                                                                                                                          
 2qfw(A) : VPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKF 
           ________________________________________________________________________________________________________________________ 

           _________________________________________________293_________305__________________________________342_346_350_354_______ 
 2qfx(A) : EQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANIL 
         :                                                                                                                          
 2qfw(A) : EQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANIL 
           _________________________________________________293_________305__________________________________342_346_350_354_______ 

           __________________________________________________                                                                       
 2qfx(A) : ESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKS                                                                       
         :                                                                                                                          
 2qfw(A) : ESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEI**                                                                       
           __________________________________________________                                                                       

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		6.1
Translation
(A) 		-0.2
Closure
(%) 		87.5
Bending Residues
( green ) 		  6 - 9
  12 - 13
  37 - 38
  44 - 45
  55 - 56
  69 - 70
  95 - 96
  112 - 113
  118 - 123
  293 - 296
  305 - 306
  342 - 343
  346 - 347
  350 - 351
  354 - 355
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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