Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Metabotropic Glutamate Receptor Subtype 1
  Conformer 1
(PDB) 		1ewt (A)
  Conformer 2
(PDB) 		1iss (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 294 0.56   38 - 208   233 - 234   236 - 236   343 - 481   501 - 506
2 154 0.62   209 - 232   235 - 235   237 - 342   482 - 500   507 - 510

Sequence


           ________________________________________________________________________________________________________________________ 
 1ewt(A) : QRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRkPIAGVIGPGSSSVAIQVQNLLQ 
         :                                                                                                                          
 1iss(A) : *RSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLI---kPIAGVIGPGSSSVAIQVQNLLQ 
           ________________________________________________________________________________________________________________________ 

           _____________________________208_____________________232________________________________________________________________ 
 1ewt(A) : LFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTV 
         :                                                                                                                          
 1iss(A) : LFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTV 
           _____________________________208_____________________232________________________________________________________________ 

           __________________________________________341___________________________________________________________________________ 
 1ewt(A) : RGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINA 
         :                                                                                                                          
 1iss(A) : RGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINA 
           __________________________________________341___________________________________________________________________________ 

           ______________________________________________________________481________________500___506______                         
 1ewt(A) : IYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKI                         
         :                                                                                                                          
 1iss(A) : IYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKI                         
           ______________________________________________________________481________________500___506______                         

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		6.5
Translation
(A) 		0.1
Closure
(%) 		61.6
Bending Residues
( green ) 		  208 - 209
  232 - 240
  341 - 343
  481 - 482
  500 - 501
  506 - 507
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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