Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Metabotropic Glutamate Receptor Subtype 1
  Conformer 1
(PDB) 		4xar (A)
  Conformer 2
(PDB) 		5cnm (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 266 1.02   32 - 194   327 - 463
2 153 1.67   195 - 326   464 - 493

Sequence


           ________________________________________________________________________________________________________________________ 
 4xar(A) : RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASL--lLIAGVIGGSYSSVSIQVANLLRLFQIPQI 
         :                                                                                                                          
 5cnm(A) : RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLiPLLIAGVIGGSYSSVSIQVANLLRLFQIPQI 
           ________________________________________________________________________________________________________________________ 

           _____________________193________________________________________________________________________________________________ 
 4xar(A) : SYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNISIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAAS 
         :                                                                                                                          
 5cnm(A) : SYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNISIATAEKVG---iRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAAS 
           _____________________193________________________________________________________________________________________________ 

           __________________________________326___________________________________________________________________________________ 
 4xar(A) : RANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSL----rVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLC 
         :                                                                                                                          
 5cnm(A) : RANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQnHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLC 
           __________________________________326___________________________________________________________________________________ 

           ________________________________________________463_____________________________________________                         
 4xar(A) : PNTTKLCDAMKILDGKKLYKDYLLKINFTAP-----dADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSE                         
         :                                                                                                                          
 5cnm(A) : PNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQ------sYLKVGHWAETLSLDVN*************                         
           ________________________________________________463_____________________________________________                         

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		30.5
Translation
(A) 		0.4
Closure
(%) 		94.8
Bending Residues
( green ) 		  193 - 195
  326 - 327
  463 - 465
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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