Non-Ribosomal Peptide Synthetase Modules

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Non-Ribosomal Peptide Synthetase Modules
  Conformer 1
(PDB) 		7c1h (A)
  Conformer 2
(PDB) 		7c1l (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 213 1.8   177 - 279   281 - 282   288 - 352   371 - 428
2 191 1.18   10 - 176   280 - 280   283 - 287   353 - 370

Sequence


           ________________________________________________________________________________________________________________________ 
 7c1h(A) : ********STTYALSAAQTEIWLAQQLYPDSPVYNIAQYTVIEGVIEPAVFEAALRQVIDEADTLRLQFIDSDDGLRQRIGTPAWSMPVLDLTAQADPQAAAQAWMRADYQQPVNLTQGP 
         :                                                                                                                          
 7c1l(A) : SHMDASVMSTTYALSAAQTEIWLAQQLYPDSPVYNIAQYTVIEGVIEPAVFEAALRQVIDEADTLRLQFIDSDDGLRQRIGTPAWSMPVLDLTAQADPQAAAQAWMRADYQQPVNLTQGP 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________176______________________________________________________________ 
 7c1h(A) : LFCYALLKVAPAQWMWYQRYHHIMMDGYGRYLIAQRVAYVYSALCEGTTPAECDFGSILQLLESDAQYQISAQRAQDEAYWLKHCANWSEPATLAS-------qRLRQTTYLAIQA---- 
         :                                                                                                                          
 7c1l(A) : LFCYALLKVAPAQWMWYQRYHHIMMDGYGAYLIAQRVAYVYSALCEGTTPAECDFGSILQLLESDAQYQISAQRAQDEAYWLKHCANWSEPATLASRSAPVLQQRLRQTTYLAIQALGDT 
           _______________________________________________________176______________________________________________________________ 

           _________________________________274__________287_________________________________________________________347___________ 
 7c1h(A) : --dARRLAQFMTAAMAAYLYRFTGEQDVVLGLPVKVRFGADRHIPGMKSNTLPLRLTMRPGMNLSSLMQQAAQEMQSGLRHQRYPSEALRRQLGMP--qRLFGTTVNVMPFDLDLSFGGY 
         :                                                                                                                          
 7c1l(A) : APDARRLAQFMTAAMAAYLYRFTGEQDVVLGLPVKVRFGADRHIPGMKSNTLPLRLTMRPGMNLSSLMQQAAQEMQSGLRHQRYPSEALRRQLGMPSGQRLFGTTVNVMPFDLDLSFGGY 
           _________________________________274__________287_________________________________________________________347___________ 

           ________369______________________________________________________________                                                
 7c1h(A) : SATNHNLLNGPAEDLMLGVYWTPGSHQLRIDFDANPACYTPEGLGAHQRRFIRFMQVLAADATQPIDSIDLLD                                                
         :                                                                                                                          
 7c1l(A) : SATNHNLLNGPAEDLMLGVYWTPGSHQLRIDFDANPACYTPEGLGAHQRRFIRFMQVLAADATQPIDSIDLL*                                                
           ________369______________________________________________________________                                                

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		12.7
Translation
(A) 		1.5
Closure
(%) 		92.8
Bending Residues
( green ) 		  176 - 177
  274 - 283
  287 - 288
  347 - 353
  369 - 371
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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