Pyruvate Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Pyruvate Kinase
  Conformer 1
(PDB) 		5wrp (C)
  Conformer 2
(PDB) 		5ws9 (C)
  Window Length 11
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 320 6.2   30 - 36   52 - 457
2 21 5.87   14 - 29   37 - 41

Sequence


           _______________________________________________________________________________________________________________________2 
 5wrp(C) : *********************************************************************************************TRRGKIVCTLGPATQRDDLVRALVEAG 
         :                                                                                                                          
 5ws9(C) : TRRGKIVCTLGPATQRDDLVRALVEAGMDVARMNFSHGDYDDHKVAYERVRVASDATGRAVGVLADLQGPKIRLGRFASGATHWAEGETVRITVGACEGSHDRVSTTYKRLAQDAVAGDR 
           ______________________________________________________________________________________________________________________12 

           9_______________________________________________________________________________________________________________________ 
 5wrp(C) : MDVARMNFSHGDYDDHKVAYERVR---VASDATGR---A----VGVLADLQGPtAPALSEKDIEDLTFALNLGVDMVALSFVRSPADVELVHEVMDRIGRRVPVIAKLEKPEAIDNLEAI 
         :                                                                                                                          
 5ws9(C) : VLVDDGKVALVVDAVEGDDVVCTVVEGGPVSDNKGISLPGMNVTAPALSEKDIEDLTFALNLGVDMVALSFVRSPADVELVHEVMDRIGRRVPVIAKLEKPEAIDNLEAIVLAFDAVMVA 
           2_______________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 5wrp(C) : VLAFDAVMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIICAVEENSTAAPPLTHIPRTKR 
         :                                                                                                                          
 5ws9(C) : RGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIICAVEENSTAAPPLTHIPRTKRGVISYAARDI 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 5wrp(C) : GVISYAARDIGERLDAKALVAFTQSGDTVRRLARLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVPKMQSTDGMIRQVDKSLLELARYKRGDLVVIVAGAPPGTVGSTNLIHVHRIGEDD 
         :                                                                                                                          
 5ws9(C) : GERLDAKALVAFTQSGDTVRRLARLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVPKMQSTDGMIRQVDKSLLELARYKRGDLVVIVAGAPPGTVGSTNLIHVHRIGEDDV********* 
           ________________________________________________________________________________________________________________________ 

           _                                                                                                                        
 5wrp(C) : V                                                                                                                        
         :                                                                                                                          
 5ws9(C) : *                                                                                                                        
           _                                                                                                                        

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		133.4
Translation
(A) 		-25.2
Closure
(%) 		55.9
Bending Residues
( green ) 		  29 - 62
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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