DynDom - Protein Domain Motions

Retinal-Specific Phospholipid-Transporting Atpase Abca4

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Retinal-Specific Phospholipid-Transporting Atpase Abca4
Conformer 1 (PDB)	7lkp (A)
Conformer 2 (PDB)	7lkz (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	1208	6.39	5 - 50 331 - 344 644 - 772 776 - 777 787 - 1394 1666 - 2250
2	683	2.7	51 - 330 345 - 643 773 - 775 778 - 786 1395 - 1665

Sequence

`______________________________________________50________________________________________________________________________` `7lkp(A) : FVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKAMPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQHL` `:` `7lkz(A) : FVRQIQLLLWKNWTLRKRQKIRFVVELVWPLSLFLVLIWLRNANPLYSHHECHFPNKAMPSAGMLPWLQGIFCNVNNPCFQSPTPGESPGIVSNYNNSILARVYRDFQELLMNAPESQHL` `______________________________________________50________________________________________________________________________` `____________________________________________________________________327_________________________________________________` `7lkp(A) : GRIWTELHILSQFMDsWGGILSDMSPRIQEFIHRPSMQDLLWVTRPLMQNGGPETFTKLMGILSDLLCGYPEGGGSRVLSFNWYEDNNYKAFLGIDSTRKDPIYSYDRRTTSFCNALIQS` `:` `7lkz(A) : GRIWTELHILSQFMD-wGGILSDMSPRIQEFIHRPSMQDLLWVTRPL----gPETFTKLMGILSDLLCGYPEGGG-------wYEDNNYKAFLG-----------yDRRTTSFCNALIQS` `____________________________________________________________________327_________________________________________________` `________________________________________________________________________________________________________________________` `7lkp(A) : LESNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEELEHVRKLVKAWEEVGPQIWYFFDNSTQMNMIRDTLGNPTVKDFLNRQLiTAEAILNFLYKGPRESQFDWRDIFNIT` `:` `7lkz(A) : LESNPLTKIAWRAAKPLLMGKILYTPDSPAARRILKNANSTFEELEHVRKLVKAWEEVGPQIWYFFDNSTQMNMIRDTLGNPTVKDFLNRQL-------------------dWRDIFNIT` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7lkp(A) : DRTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEENMFWAGVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGITRSQVQA` `:` `7lkz(A) : DRTLRLVNQYLECLVLDKFESYNDETQLTQRALSLLEENMFWAGVVFPDMYPWTSSLPPHVKYKIRMDIDVVEKTNKIKDRYWDSGPRADPVEDFRYIWGGFAYLQDMVEQGITRSQVQA` `________________________________________________________________________________________________________________________` `______________643_______________________________________________________________________________________________________` `7lkp(A) : EAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIM` `:` `7lkz(A) : EAPVGIYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRILHYSDPFILFLFLLAFSTATIM` `______________643_______________________________________________________________________________________________________` `_______________________772___________786________________________________________________________________________________` `7lkp(A) : LCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFPGDYG` `:` `7lkz(A) : LCFLLSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNIGNSPTEGDEFSFLLSMQMMLLDAAVYGLLAWYLDQVFPGDYG` `_______________________772___________786________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7lkp(A) : TPLPWYF----------sFFEREHPGWVPGVCVKNLVKI---------dRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHL` `:` `7lkz(A) : TPLPWYFLLQESYWLhDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLVGGRDIETSLDAVRQSLGMCPQHNILFHHL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7lkp(A) : TVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRL` `:` `7lkz(A) : TVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDQPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7lkp(A) : YCSGTPLFLKNCFGTGLYLTLVRK----lDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTp-GPQLNTGTQLVLQ` `:` `7lkz(A) : YCSGTPLFLKNCFGTGLYLTLVRKMKqVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSpQLNTGTQLVLQ` `________________________________________________________________________________________________________________________` `_____________________________________1394_______________________________________________________________________________` `7lkp(A) : HVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQL` `:` `7lkz(A) : HVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQL` `_____________________________________1394_______________________________________________________________________________` `________________________________________________________________________________________________________________________` `7lkp(A) : FQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGP` `:` `7lkz(A) : FQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGP` `________________________________________________________________________________________________________________________` `_________________________________________________________________1662___________________________________________________` `7lkp(A) : ITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQ` `:` `7lkz(A) : ITREASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQ` `_________________________________________________________________1662___________________________________________________` `________________________________________________________________________________________________________________________` `7lkp(A) : FISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLL` `:` `7lkz(A) : FISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIFIGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7lkp(A) : IVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFkEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVR` `:` `7lkz(A) : IVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHF---FLdEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVR` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7lkp(A) : PGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAI` `:` `7lkz(A) : PGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEEIEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAI` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7lkp(A) : ALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIK-lLPDLNPVEQFFQGNFPGSVQRERHYNMLQ` `:` `7lkz(A) : ALIGCPPLVLLDQPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSlLPDLNPVEQFFQGNFPGSVQRERHYNMLQ` `________________________________________________________________________________________________________________________` `______________________________________________` `7lkp(A) : FQVSSSSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQT` `:` `7lkz(A) : FQVSSSSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQ*` `______________________________________________`

Morph

Morph animation in progress.
Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	47.0
Translation (A)	-0.9
Closure (%)	6.6
Bending Residues ( green )	50 - 51 327 - 350 643 - 644 772 - 773 775 - 778 786 - 787 1394 - 1400 1662 - 1673
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

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