Serine/threonine-Protein Kinase Pak 4

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Serine/threonine-Protein Kinase Pak 4
  Conformer 1
(PDB) 		2cdz (A)
  Conformer 2
(PDB) 		1yhw (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 240 1.53   302 - 316   354 - 383   386 - 390   395 - 585
2 41 1.72   317 - 353   384 - 385   391 - 394

Sequence


           _______________316__________________________________353___________________________383________394________________________ 
 2cdz(A) : VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIA--TVRgKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA 
         :                                                                                                                          
 1yhw(A) : *SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIA 
           _______________265__________________________________302___________________________332________343________________________ 

           ________________________________________________________________________________________________________________________ 
 2cdz(A) : AVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRK-lVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNL 
         :                                                                                                                          
 1yhw(A) : AVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNP 
           ________________________________________________________________________________________________________________________ 

           ______________________________________________________                                                                   
 2cdz(A) : HKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRT**                                                                   
         :                                                                                                                          
 1yhw(A) : EKLSAIFRDFLNRCLDMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEAT                                                                   
           ______________________________________________________                                                                   

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		19.5
Translation
(A) 		-0.2
Closure
(%) 		98.9
Bending Residues
( green ) 		  316 - 317
  353 - 354
  383 - 391
  394 - 395
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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