DynDom - Protein Domain Motions

Sialidase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Sialidase
Conformer 1 (PDB)	1euu (A)
Conformer 2 (PDB)	1w8n (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	422	0.81	50 - 411 416 - 422 424 - 448 454 - 463 467 - 469 473 - 476 479 - 480 486 - 494
2	174	0.89	412 - 415 423 - 423 449 - 453 464 - 466 470 - 472 477 - 478 481 - 485 495 - 645

Sequence

`________________________________________________________________________________________________________________________` `1euu(A) : GEPLYTEQDLAVNGREGFPNYRIPALTVTPDGDLLASYDGRPTGIDAPGPNSILQRRSTDGGRTWGEQQVVSAGQTTAPIKGFSDPSYLVDRETGTIFNFHVYSQRQGFAGSRPGTDPAD` `:` `1w8n(A) : GEPLYTEQDLAVNGREGFPNYRIPALTVTPDGDLLASYDGRPTGIGAPGPNSILQRRSTDGGRTWGEQQVVSAGQTTAPIKGFSDPSYLVDRETGTIFNFHVYSQRQGFAGSRPGTDPAD` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1euu(A) : PNVLHANVATSTDGGLTWSHRTITADITPDPGWRSRFAASGEGIQLRYGPHAGRLIQQYTIINAAGAFQAVSVYSDDHGRTWRAGEAVGVGMDENKTVELSDGRVLLNSRDSARSGYRKV` `:` `1w8n(A) : PNVLHANVATSTDGGLTWSHRTITADITPDPGWRSRFAASGEGIQLRYGPHAGRLIQQYTIINAAGAFQAVSVYSDDHGRTWRAGEAVGVGMDENKTVELSDGRVLLNSRDSARSGYRKV` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1euu(A) : AVSTDGGHSYGPVTIDRDLPDPTNNASIIRAFPDAPAGSARAKVLLFSNAASQTSRSQGTIRMSCDDGQTWPVSKVFQPGSMSYSTLTALPDGTYGLLYEPGTGIRYANFNLAWLGGICA` `:` `1w8n(A) : AVSTDGGHSYGPVTIDRDLPDPTNNASIIRAFPDAPAGSARAKVLLFSNAASQTSRSQGTIRMSCDDGQTWPVSKVFQPGSMSYSTLTALPDGTYGLLYEPGTGIRYANFNLAWLGGICA` `________________________________________________________________________________________________________________________` `__411_415____422_______________________448__453_______463___469____476______485____492__________________________________` `1euu(A) : PFTIPDVALEPGQQVTVPVAVTNQSGIAVPKPSLQLDASPDWQVQGSVEPLMPGRQAKGQVTITVPAGTTPGRYRVGATLRTSAGNASTTFTVTVGLLDQARMSIADVDSEETAREDGRA` `:` `1w8n(A) : PFTIPDVALEPGQQVTVPVAVTNQSGIAVPKPSLQLDASPDWQVQGSVEPLMPGRQAKGQVTITVPAGTTPGRYRVGATLRTSAGNASTTFTVTVGLLDQARMSIADVDSEETAREDGRA` `__411_415____422_______________________448__453_______463___469____476______485____492__________________________________` `________________________________________________________________________________________________________________________` `1euu(A) : SNVIDGNPSTFWHTEWSRADAPGYPHRISLDLGGTHTISGLQYTRRQNSANEQVADYEIYTSLNGTTWDGPVASGRFTTSLAPQRAVFPARDARYIRLVALSEQTGHKYAAVAELEVEGQ` `:` `1w8n(A) : SNVIDGNPSTFWHTEWSRADAPGYPHRISLDLGGTHTISGLQYTRRQNSANEQVADYEIYTSLNGTTWDGPVASGRFTTSLAPQRAVFPARDARYIRLVALSEQTGHKYAAVAELEVEGQ` `________________________________________________________________________________________________________________________` `_` `1euu(A) : R` `:` `1w8n(A) : R` `_`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	8.8
Translation (A)	0.7
Closure (%)	87.2
Bending Residues ( green )	411 - 412 415 - 416 422 - 424 448 - 449 453 - 454 463 - 464 466 - 467 469 - 470 472 - 473 476 - 481 485 - 486 492 - 495
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

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